Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

2-Chloro-4-(methylsulfonyl)pyrimidine

  • CAS No. 1233026-31-7

  • Cat. No. CS-W021647
  • Molecule weight192.62
  • Purity≥97%
  • MDL No.MFCD16659665

*For research and further manufacturing use only, not for direct human use.

2-Chloro-4-(methylsulfonyl)pyrimidine|CS-W021647

Structure of 1233026-31-7

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 1233026-31-7
  • Cat. No. CS-W021647
  • Purity ≥97%
  • MDL No. MFCD16659665
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅ClN₂O₂S
  • Molecular Weight 192.62
  • Synonym(s) None
  • SMILES O=S(C1=NC(Cl)=NC=C1)(C)=O

Description

2-Chloro-4-(methylsulfonyl)pyrimidine serves as a pivotal building block in medicinal chemistry, featuring a chlorinated pyrimidine core paired with a robust methylsulfonyl group. This combination enables direct incorporation into kinase inhibitors and other bioactive scaffolds, where the electron-withdrawing sulfonyl moiety enhances target affinity and metabolic stability under standard conditions.

Application

2-Chloro-4-(methylsulfonyl)pyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds. The chloro group at C2 facilitates nucleophilic substitution with amines, thiols, and other heterocyclic nucleophiles, while the methylsulfonyl substituent enhances solubility and metabolic stability. Its bench-stable nature and compatibility with standard coupling protocols make it well-suited for modular synthesis workflows in API development.

Synthesis

  • Route1

    References

    • Baiazitov, Ramil; Du, Wu; Lee, Chang-Sun; Hwang, Seongwoo; Almstead, Neil G.; Moon, Young-Choon Synthesis (Germany), 2013 , vol. 45, # 13 art. no. SS-2013-C0253-OP, p. 1764 - 1784

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   59.92
  • LogP   0.5335
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 2-Chloro-4-(methylsulfonyl)pyrimidine sigma2-Chloro-4-(methylsulfonyl)pyrimidine manufacturer2-Chloro-4-(methylsulfonyl)pyrimidine price2-Chloro-4-(methylsulfonyl)pyrimidine structure2-Chloro-4-(methylsulfonyl)pyrimidine SDSbuy 2-Chloro-4-(methylsulfonyl)pyrimidine2-Chloro-4-(methylsulfonyl)pyrimidine supplier2-Chloro-4-(methylsulfonyl)pyrimidine uses2-Chloro-4-(methylsulfonyl)pyrimidine molecular weightprice of 2-Chloro-4-(methylsulfonyl)pyrimidine2-Chloro-4-(methylsulfonyl)pyrimidine chemical name formula of 2-Chloro-4-(methylsulfonyl)pyrimidine
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label