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Structure of 1233026-31-7
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2-Chloro-4-(methylsulfonyl)pyrimidine serves as a pivotal building block in medicinal chemistry, featuring a chlorinated pyrimidine core paired with a robust methylsulfonyl group. This combination enables direct incorporation into kinase inhibitors and other bioactive scaffolds, where the electron-withdrawing sulfonyl moiety enhances target affinity and metabolic stability under standard conditions.
2-Chloro-4-(methylsulfonyl)pyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds. The chloro group at C2 facilitates nucleophilic substitution with amines, thiols, and other heterocyclic nucleophiles, while the methylsulfonyl substituent enhances solubility and metabolic stability. Its bench-stable nature and compatibility with standard coupling protocols make it well-suited for modular synthesis workflows in API development.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: