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CS-W001157 4
Total: USD 88.00

6-Fluoropyridin-2-ol

  • CAS No. 50543-23-2

  • Cat. No. CS-W022502
  • Purity≥95%
  • MDL No.MFCD03092938

*For research and further manufacturing use only, not for direct human use.

6-Fluoropyridin-2-ol|CS-W022502

Structure of 50543-23-2

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General Information

  • CAS No. 50543-23-2
  • Cat. No. CS-W022502
  • Purity ≥95%
  • MDL No. MFCD03092938
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄FNO
  • Molecular Weight 113.09
  • Synonym(s) 2-Fluoro-6-hydroxypyridine
  • SMILES O=C1NC(F)=CC=C1

Description

6-Fluoropyridin-2-ol features a fluorine atom at the 6-position and a hydroxyl group at the 2-position on a pyridine ring, creating a polar, electron-deficient heterocycle. This arrangement enhances solubility and reactivity in cross-coupling and derivatization reactions. The compound exhibits bench-stable handling characteristics under standard conditions.

Application

6-Fluoropyridin-2-ol serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C2 position via nucleophilic substitution. Its stability under standard reaction conditions and compatibility with diverse coupling protocols facilitate efficient access to fluorinated heterocycles. The molecule functions effectively as a key intermediate in the synthesis of kinase inhibitors and other bioactive scaffolds, offering predictable reactivity and straightforward purification.

Synthesis

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    • In-stock
      6-Fluoropyridin-2-ol|CS-W022502
      50543-23-2

    References

    • US4320122 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   32.86
  • LogP   0.514
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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