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CS-W001157 4
Total: USD 88.00

3-Chloro-2-pyrazine-carboxylic acid

  • CAS No. 27398-39-6

  • Cat. No. CS-W004253
  • Purity≥98%
  • MDL No.MFCD01318438

*For research and further manufacturing use only, not for direct human use.

3-Chloro-2-pyrazine-carboxylic acid|CS-W004253

Structure of 27398-39-6

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General Information

  • CAS No. 27398-39-6
  • Cat. No. CS-W004253
  • Purity ≥98%
  • MDL No. MFCD01318438
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClN₂O₂
  • Molecular Weight 158.54
  • Synonym(s) 3-chloropyrazine-2-carboxylic Acid
  • SMILES OC(=O)c1nccnc1Cl

Description

3-Chloro-2-pyrazine-carboxylic acid features a pyrazine core bearing a chloro substituent at the 3-position and a carboxylic acid group at the 2-position, enabling direct integration into heterocyclic scaffolds. This electron-deficient motif facilitates coupling reactions under mild conditions, offering reliable access to bioactive intermediates in medicinal chemistry.

Application

3-Chloro-2-pyrazine-carboxylic acid serves as a versatile building block in the synthesis of heterocyclic pharmaceutical intermediates. Its dual functionality—pyrazine core and carboxylic acid—enables direct amidation, esterification, or coupling reactions under standard conditions. The chloro substituent facilitates nucleophilic aromatic substitution, allowing access to diverse substituted pyrazine scaffolds. Bench-stable and readily purified by recrystallization, it supports scalable synthesis in medicinal chemistry and process development workflows.

Synthesis

  • Route1

    References

    • Magnetic Resonance in Chemistry, , vol. 47, # 7 p. 617 - 624
  • Route2
    • In-stock
      Chloropyrazine|CS-W018537
      14508-49-7
    • null|null
      124-38-9
    • ~%
    • In-stock
      3-Chloro-2-pyrazine-carboxylic acid|CS-W004253
      27398-39-6

    References

    • Synthesis, , # 11 p. 881 - 884
  • Route3

    References

    • Heterocycles, , vol. 22, # 2 p. 299 - 301

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   63.08
  • LogP   0.8282
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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