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CS-W001157 4
Total: USD 88.00

6-Fluoropicolinonitrile

  • CAS No. 3939-15-9

  • Cat. No. CS-W008396
  • Purity≥98%
  • MDL No.MFCD09263323

*For research and further manufacturing use only, not for direct human use.

6-Fluoropicolinonitrile|CS-W008396

Structure of 3939-15-9

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General Information

  • CAS No. 3939-15-9
  • Cat. No. CS-W008396
  • Purity ≥98%
  • MDL No. MFCD09263323
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃FN₂
  • Molecular Weight 122.10
  • Synonym(s) 6-fluoropyridine-2-carbonitrile
  • SMILES N#CC1=NC(F)=CC=C1

Description

6-Fluoropicolinonitrile features a fluorinated pyridine core with a nitrile group at the 6-position, delivering enhanced electron-withdrawing character and improved metabolic stability. This combination enables efficient incorporation into pharmaceutical scaffolds and functional materials through transition-metal-catalyzed coupling reactions under standard conditions.

Application

6-Fluoropicolinonitrile serves as a versatile building block in synthetic organic chemistry, enabling the construction of fluorinated heterocycles and pharmaceutical intermediates. Its dual functionality—electron-deficient pyridine ring and nitrile group—facilitates nucleophilic substitution, cyclization, and transition-metal-catalyzed coupling reactions. The molecule exhibits good bench stability and compatibility with common protecting groups, making it well-suited for iterative synthesis workflows in medicinal chemistry and process development.

Synthesis

  • Route1

    References

    • Zhang, Yinsheng; Greenfield, Laura; Hong, Yang Journal of Labelled Compounds and Radiopharmaceuticals, 2011 , vol. 54, # 8 p. 411 - 417
  • Route2

    References

    • Umemoto, Teruo; Tomizawa, Ginjiro Journal of Organic Chemistry, 1989 , vol. 54, # 7 p. 1726 - 1731
  • Route3
    • null|null
      119071-55-5
    • ~76%
    • In-stock
      6-Fluoropicolinonitrile|CS-W008396
      3939-15-9

    References

    • Umemoto, Teruo; Tomizawa, Ginjiro Journal of Organic Chemistry, 1989 , vol. 54, # 7 p. 1726 - 1731

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3439
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302+H312+H332-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   36.68
  • LogP   1.09238
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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