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CS-W001157 4
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p-Tolylhydrazine hydrochloride

  • CAS No. 637-60-5

  • Cat. No. CS-W016192
  • Purity≥97%
  • MDL No.MFCD00012940

*For research and further manufacturing use only, not for direct human use.

p-Tolylhydrazine hydrochloride|CS-W016192

Structure of 637-60-5

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General Information

  • CAS No. 637-60-5
  • Cat. No. CS-W016192
  • Purity ≥97%
  • MDL No. MFCD00012940
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₁ClN₂
  • Molecular Weight 158.63
  • Synonym(s) 4-Methylphenylhydrazine Hydrochloride
  • SMILES CC1=CC=C(NN)C=C1.Cl

Description

p-Tolylhydrazine hydrochloride offers a bench-stable, moisture-tolerant platform for constructing hydrazone-based scaffolds in synthetic and medicinal chemistry. The para-methyl group enhances electron density at the hydrazine nitrogen, improving reactivity in condensation reactions with aldehydes and ketones. This derivative facilitates efficient access to bioactive heterocycles and functionalized intermediates under standard conditions.

Application

p-Tolylhydrazine hydrochloride serves as a reliable building block for the synthesis of heterocyclic compounds, particularly in the construction of pyrazoles and triazoles via condensation reactions. Its stability under ambient conditions and ease of handling make it well-suited for bench-scale applications. The molecule exhibits good functional group tolerance and facilitates efficient coupling with carbonyl-containing substrates, enabling straightforward access to biologically relevant scaffolds.

Synthesis

  • Route1
    • null|null
      106-49-0
    • ~61%
    • In-stock
      p-Tolylhydrazine hydrochloride|CS-W016192
      637-60-5

    References

    • UCHREZHDENIE ROSSIISKOI AKADEMII NAUK INSTITUT MOLEKULYARNOI BIOLOGII IM. V.A. ENGELGARDTA RAN (IMB RAN) Patent: EP2157088 A1, 2010 ; Location in patent: Page/Page column 41-42 ;
  • Route2
    • null|null
      106-38-7
    • ~67%
    • In-stock
      p-Tolylhydrazine hydrochloride|CS-W016192
      637-60-5

    References

    • Kurandina, Daria V.; Eliseenkov, Eugene V.; Ilyin, Petr V.; Boyarskiy, Vadim P. Tetrahedron, 2014 , vol. 70, # 26 p. 4043 - 4048
  • Route3
    • null|null
      40594-88-5
    • ~99%
    • In-stock
      p-Tolylhydrazine hydrochloride|CS-W016192
      637-60-5

    References

    • Mauger, Christelle C.; Mignani, Gerard A. Organic Process Research and Development, 2004 , vol. 8, # 6 p. 1065 - 1071

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06,GHS08,GHS09
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301+H311+H331-H317-H350-H410
Precautionary Statements : P261-P264-P270-P271-P272-P273-P280-P302+P352-P304+P340-P330-P361+P364-P362+P364-P391-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.05
  • LogP   1.70242
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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