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CS-W001157 4
Total: USD 88.00

(4-Fluorophenyl)hydrazine (hydrochloride)

  • CAS No. 823-85-8

  • Cat. No. CS-W007861
  • Purity≥95%
  • MDL No.MFCD00012942

*For research and further manufacturing use only, not for direct human use.

(4-Fluorophenyl)hydrazine (hydrochloride)|CS-W007861

Structure of 823-85-8

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General Information

  • CAS No. 823-85-8
  • Cat. No. CS-W007861
  • Purity ≥95%
  • MDL No. MFCD00012942
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈ClFN₂
  • Molecular Weight 162.59
  • Synonym(s) None
  • SMILES FC1=CC=C(NN)C=C1.Cl

Description

(4-Fluorophenyl)hydrazine (hydrochloride) features a fluorinated aromatic ring that enhances metabolic stability and modulates electronic properties. This bench-stable hydrazine derivative enables direct coupling in C–N bond formation, serving as a key intermediate for bioactive heterocycles and pharmaceutical scaffolds under standard conditions.

Application

(4-Fluorophenyl)hydrazine (hydrochloride) serves as a reliable building block for the synthesis of fluorinated heterocycles and azo dyes. Its well-documented reactivity enables efficient coupling in Ullmann-type reactions and facilitates the construction of biologically relevant scaffolds via cyclization pathways. The hydrochloride salt enhances bench stability and simplifies handling, while maintaining compatibility with standard synthetic workflows involving nucleophilic hydrazine derivatives.

Synthesis

  • Route1
    • null|null
      371-40-4
    • ~53%
    • In-stock
      (4-Fluorophenyl)hydrazine (hydrochloride)|CS-W007861
      823-85-8

    References

    • Zhang, Fan; Zhao, Yanfang; Sun, Li; Ding, Lu; Gu, Yucheng; Gong, Ping European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 3149 - 3157
  • Route2
    • null|null
      460-00-4
    • ~75%
    • In-stock
      (4-Fluorophenyl)hydrazine (hydrochloride)|CS-W007861
      823-85-8

    References

    • Kurandina, Daria V.; Eliseenkov, Eugene V.; Ilyin, Petr V.; Boyarskiy, Vadim P. Tetrahedron, 2014 , vol. 70, # 26 p. 4043 - 4048
  • Route3
    • null|null
      5352-95-4
    • ~88%
    • In-stock
      (4-Fluorophenyl)hydrazine (hydrochloride)|CS-W007861
      823-85-8

    References

    • Kuo; Lee; Yeh Journal of the Chinese Chemical Society, 2000 , vol. 47, # 1 p. 227 - 240

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06,GHS08,GHS09
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H317-H331-H350-H400-H410
Precautionary Statements : P261-P264-P270-P271-P272-P273-P280-P361+P364-P391-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.05
  • LogP   1.5331
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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