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CS-W001157 4
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3,5-Dimethylphenylhydrazine hydrochloride

  • CAS No. 60481-36-9

  • Cat. No. CS-W010766
  • Purity≥97%
  • MDL No.MFCD00052269

*For research and further manufacturing use only, not for direct human use.

3,5-Dimethylphenylhydrazine hydrochloride|CS-W010766

Structure of 60481-36-9

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General Information

  • CAS No. 60481-36-9
  • Cat. No. CS-W010766
  • Purity ≥97%
  • MDL No. MFCD00052269
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₃ClN₂
  • Molecular Weight 172.66
  • Synonym(s) None
  • SMILES Cl.CC1=CC(=CC(=C1)NN)C

Description

3,5-Dimethylphenylhydrazine hydrochloride features a sterically hindered arylhydrazine core with electron-donating methyl groups at the 3- and 5-positions. This configuration enhances stability and facilitates selective coupling reactions in synthetic organic chemistry. The hydrochloride salt form improves solubility and handling under standard bench conditions.

Application

3,5-Dimethylphenylhydrazine hydrochloride serves as a reliable building block for the synthesis of heterocyclic scaffolds, particularly in the construction of pyrazoles and other nitrogen-containing rings. Its stability under standard bench conditions and tolerance to common functional groups enable straightforward incorporation into multi-step sequences. The compound facilitates efficient coupling reactions and provides access to diverse analogs via condensation with carbonyl precursors, making it a practical choice for medicinal chemistry and process development workflows.

Synthesis

  • Route1
    • null|null
      108-69-0
    • ~84%
    • In-stock
      3,5-Dimethylphenylhydrazine hydrochloride|CS-W010766
      60481-36-9

    References

    • Natco Pharma Limited Patent: US2010/298351 A1, 2010 ; Location in patent: Page/Page column 31 ; US 20100298351 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.05
  • LogP   2.01084
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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