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CS-W001157 4
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4-Ethylphenylhydrazine hydrochloride

  • CAS No. 53661-18-0

  • Cat. No. CS-W002839
  • Purity≥97%
  • MDL No.MFCD01861267

*For research and further manufacturing use only, not for direct human use.

4-Ethylphenylhydrazine hydrochloride|CS-W002839

Structure of 53661-18-0

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General Information

  • CAS No. 53661-18-0
  • Cat. No. CS-W002839
  • Purity ≥97%
  • MDL No. MFCD01861267
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₃ClN₂
  • Molecular Weight 172.66
  • Synonym(s) (4-ethylphenyl)diazanium chloride
  • SMILES CCc1ccc(cc1)NN.Cl

Description

4-Ethylphenylhydrazine hydrochloride features a conjugated hydrazine moiety attached to an ethyl-substituted phenyl ring, enabling effective coupling in hydrazone formation. This bench-stable derivative delivers high reactivity under standard conditions, facilitating efficient incorporation into functionalized intermediates for pharmaceutical and materials applications.

Application

4-Ethylphenylhydrazine hydrochloride serves as a reliable building block for heterocyclic synthesis, particularly in the construction of pyrazoles and other nitrogen-rich scaffolds. Its well-documented reactivity facilitates efficient coupling with carbonyl compounds under mild conditions. The hydrochloride salt enhances bench stability and simplifies purification, enabling consistent performance in medicinal chemistry and process development workflows.

Synthesis

  • Route1

    References

    • Bignon, Eric; Bras, Jean Pierre; De Cointet, Paul; Despeyroux, Pierre; Frehel, Daniel; Gully, Danielle Patent: US2004/43995 A1, 2004 ; Location in patent: Page 13 ; US 20040043995 A1
  • Route2

    References

    • Kurandina, Daria V.; Eliseenkov, Eugene V.; Ilyin, Petr V.; Boyarskiy, Vadim P. Tetrahedron, 2014 , vol. 70, # 26 p. 4043 - 4048

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.05
  • LogP   1.9564
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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