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CS-W001157 4
Total: USD 88.00

4-Cyanophenylhydrazine hydrochloride

  • CAS No. 2863-98-1

  • Cat. No. CS-W009104
  • Purity≥98%
  • MDL No.MFCD00673994

*For research and further manufacturing use only, not for direct human use.

4-Cyanophenylhydrazine hydrochloride|CS-W009104

Structure of 2863-98-1

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General Information

  • CAS No. 2863-98-1
  • Cat. No. CS-W009104
  • Purity ≥98%
  • MDL No. MFCD00673994
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈ClN₃
  • Molecular Weight 169.61
  • Synonym(s) None
  • SMILES NNC1=CC=C(C#N)C=C1.Cl

Description

4-Cyanophenylhydrazine (hydrochloride) features a para-cyano group that enhances electron-withdrawing character, enabling efficient coupling in heterocyclic synthesis. This bench-stable derivative integrates readily into azo and triazine scaffolds, offering high reactivity under mild conditions with predictable regiochemistry.

Application

4-Cyanophenylhydrazine (hydrochloride) serves as a versatile building block for the synthesis of heterocyclic scaffolds, particularly in the construction of phenylhydrazone derivatives and triazoles. Its cyanide group enhances electrophilicity at the aromatic ring, enabling efficient coupling reactions and facilitating downstream functionalization. The hydrochloride salt improves bench stability and solubility, simplifying handling and purification in standard organic workflows.

Synthesis

  • Route1

    References

    • Chandna, Nisha; Kumar, Satish; Kaushik, Pawan; Kaushik, Dhirender; Roy, Somendu K.; Gupta, Girish K.; Jachak, Sanjay M.; Kapoor, Jitander K.; Sharma, Pawan K. Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 15 p. 4581 - 4590
  • Route2
    • In-stock
      4-Amino-3-iodobenzonitrile|CS-W003146
      33348-34-4
    • ~0%
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      1019995-59-5
    • In-stock
      4-Cyanophenylhydrazine hydrochloride|CS-W009104
      2863-98-1

    References

    • Stukenbrock, Hendrik; Mussmann, Rainer; Geese, Marcus; Ferandin, Yoan; Lozach, Olivier; Lemcke, Thomas; Kegel, Simone; Lomow, Alexander; Burk, Ulrike; Dohrmann, Cord; Meijer, Laurent; Austen, Matthias; Kunick, Conrad Journal of Medicinal Chemistry, 2008 , vol. 51, # 7 p. 2196 - 2207

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302+H312+H332-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   61.84
  • LogP   1.26568
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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