Fmoc-NH-PEG5-CH2COOH

Name: Fmoc-NH-PEG5-CH2COOH
Brand: ChemScene
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CAS No. 635287-26-2
Cat. No. CS-0110024
Purity≥97%
MDL No.MFCD26142982

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 635287-26-2

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General Information

CAS No. 635287-26-2
Cat. No. CS-0110024
Purity ≥97%
MDL No. MFCD26142982
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₇H₃₅NO₉
Molecular Weight 517.57
Synonym(s) None
SMILES O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)NCCOCCOCCOCCOCCOCC(O)=O

Description

Fmoc-NH-PEG5-CH2COOH is a bifunctional linker featuring a fluorenylmethoxy carbonyl (Fmoc)-protected amine terminus and a carboxylic acid handle, connected via a five-unit polyethylene glycol (PEG) spacer. This design enables efficient solid-phase peptide synthesis and conjugation workflows while enhancing solubility in aqueous and organic media. The PEG5 chain provides flexibility and reduced aggregation, facilitating downstream applications in bioconjugation and drug delivery systems.

Application

Fmoc-NH-PEG5-CH2COOH serves as a versatile bifunctional linker for peptide synthesis and conjugation chemistry. The Fmoc group enables orthogonal protection in solid-phase peptide synthesis, while the PEG5 spacer provides enhanced solubility and reduced aggregation. The terminal carboxylic acid facilitates amide coupling or bioconjugation reactions, making it ideal for constructing peptide-drug conjugates, protein labeling reagents, and functionalized biomaterials with improved pharmacokinetic properties.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 121.78
LogP 2.6927
H_Acceptors 8
H_Donors 2
Rotatable_Bonds 19

Other Classifications

Building Blocks Functional Group Fmoc

Building Blocks Functional Group PEG

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Life Science Linker Fmoc PEG

Life Science Linker PEG Acid

Life Science ADC Related Compound Cleavable Linker

Life Science PROTAC PROTAC Linker

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Chemical Biology PEGylation Monofunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation Heterobifunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation PEG Oligomers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Biochemicals and Reagents Bioconjugation PEGylation Reagents and PEG Spacers

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

Key Words

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Fmoc-NH-PEG5-CH2COOH

CAS No. 635287-26-2

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