Fmoc-NH-PEG8-CH2COOH

Name: Fmoc-NH-PEG8-CH2COOH
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CAS No. 868594-52-9
Cat. No. CS-0110025
Purity≥98%
MDL No.MFCD27635163

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 868594-52-9
Cat. No. CS-0110025
Purity ≥98%
MDL No. MFCD27635163
Storage -20°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₃₃H₄₇NO₁₂
Molecular Weight 649.73
Synonym(s) None
SMILES O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)NCCOCCOCCOCCOCCOCCOCCOCCOCC(O)=O

Description

Fmoc-NH-PEG8-CH2COOH is a bifunctional linker featuring a fluorenylmethoxy carbonyl (Fmoc) protected amine and a terminal carboxylic acid. This PEG8 spacer provides enhanced solubility and flexibility, enabling efficient conjugation in peptide synthesis and bioconjugation workflows. The Fmoc group ensures orthogonal protection for amine-directed reactions, while the carboxylic acid facilitates coupling via standard activation methods.

Application

Fmoc-NH-PEG8-CH2COOH serves as a versatile bifunctional linker for peptide and biomolecule conjugation. The Fmoc group enables orthogonal protection during solid-phase synthesis, while the PEG8 spacer provides enhanced solubility and reduced aggregation. The terminal carboxylic acid facilitates efficient coupling to amines via standard amide bond formation, offering reliable functionality in bioconjugation workflows and macromolecular engineering applications.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 149.47
LogP 2.7425
H_Acceptors 11
H_Donors 2
Rotatable_Bonds 28

Other Classifications

Life Science PROTAC PROTAC Linker

Life Science Linker Fmoc PEG

Life Science Linker PEG Acid

Life Science ADC Related Compound Cleavable Linker

Building Blocks Functional Group Fmoc

Building Blocks Functional Group PEG

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Chemical Biology PEGylation Monofunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation Heterobifunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation PEG Oligomers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Biochemicals and Reagents Bioconjugation PEGylation Reagents and PEG Spacers

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Key Words

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Fmoc-NH-PEG8-CH2COOH

CAS No. 868594-52-9

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