Lot numbers can be found on the outside label of a product:
Fmoc-NH-PEG4-CH2COOH
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CAS No. 437655-95-3
- Cat. No. CS-0105401
- Purity≥98%
- MDL No.MFCD26142981
*For research and further manufacturing use only, not for direct human use.
Structure of 437655-95-3
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General Information
- CAS No. 437655-95-3
- Cat. No. CS-0105401
- Purity ≥98%
- MDL No. MFCD26142981
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₂₅H₃₁NO₈
- Molecular Weight 473.52
- Synonym(s) None
- SMILES O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)NCCOCCOCCOCCOCC(O)=O
Description
Fmoc-NH-PEG4-CH2COOH is a bifunctional linker featuring a fluorenylmethoxycarbonyl (Fmoc)-protected amine, a four-ethylene glycol (PEG4) spacer, and a terminal carboxylic acid. This structure enables efficient solid-phase synthesis of peptide-polymer conjugates and bioactive molecule immobilization. The PEG4 chain imparts solubility and reduces aggregation, while the Fmoc group allows for selective deprotection under mild basic conditions. The carboxylic acid facilitates coupling to primary amines via standard activation methods.
Application
Fmoc-NH-PEG4-CH2COOH serves as a versatile bifunctional linker for peptide synthesis and conjugation workflows. The Fmoc group enables orthogonal protection in solid-phase peptide synthesis, while the PEG4 spacer provides solubility and reduced aggregation. The terminal carboxylic acid facilitates coupling to amines via standard amide bond formation, making it ideal for preparing peptide-drug conjugates, protein bioconjugates, and functionalized resins with enhanced solubility and stability.
Synthesis
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Route1
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894427-95-3 - ~65%
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In-stock
437655-95-3
References
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N.V. ORGANON Patent: WO2007/42469 A2, 2007 ; Location in patent: Page/Page column 15; 16 ;
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Route2
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In-stock
195071-49-9 -
28920-43-6 - ~63%
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In-stock
437655-95-3
References
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Bogdan, Niculina D.; Matache, Mihaela; Meier, Veronika M.; Dobrotae, Cristian; Dumitru, Ioana; Roiban, Gheorghe D.; Funeriu, Daniel P. Chemistry - A European Journal, 2010 , vol. 16, # 7 p. 2170 - 2180
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Route3
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112-60-7 - ~%
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In-stock
437655-95-3
References
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Schmidt, Florian; Rosnizeck, Ina C.; Spoerner, Michael; Kalbitzer, Hans Robert; Koenig, Burkhard Inorganica Chimica Acta, 2011 , vol. 365, # 1 p. 38 - 48
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 112.55
- LogP 2.6761
- H_Acceptors 7
- H_Donors 2
- Rotatable_Bonds 16
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Other Classifications
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- Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers
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Key Words
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