Amino-PEG4-CH2COOH

Name: Amino-PEG4-CH2COOH
Brand: ChemScene
Availability: InStock
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CAS No. 195071-49-9
Cat. No. CS-0108846
Purity≥95%
MDL No.MFCD27977508

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 195071-49-9

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General Information

CAS No. 195071-49-9
Cat. No. CS-0108846
Purity ≥95%
MDL No. MFCD27977508
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₂₁NO₆
Molecular Weight 251.28
Synonym(s) None
SMILES O=C(O)COCCOCCOCCOCCN

Description

Amino-PEG4-CH2COOH is a bifunctional PEG-based linker featuring a primary amine at one terminus and a carboxylic acid at the other. This combination enables efficient conjugation to biomolecules via amide bond formation or coupling to activated surfaces, offering enhanced solubility and stability in aqueous environments.

Application

Amino-PEG4-CH2COOH serves as a versatile bifunctional linker for conjugation and polymer chemistry, combining the solubility and biocompatibility of PEG with reactive amine and carboxylic acid termini. The terminal amine enables efficient coupling to activated esters or aldehydes, while the carboxylic acid facilitates amide bond formation with amines. Its four-ethylene glycol unit provides enhanced hydrophilicity and stability in aqueous environments, making it ideal for bioconjugation, drug delivery systems, and surface functionalization.

Synthesis

Route1
- In-stock
  
  201467-81-4
- ~82%
- In-stock
  
  195071-49-9
References
- Bogdan, Niculina D.; Matache, Mihaela; Meier, Veronika M.; Dobrotae, Cristian; Dumitru, Ioana; Roiban, Gheorghe D.; Funeriu, Daniel P. Chemistry - A European Journal, 2010 , vol. 16, # 7 p. 2170 - 2180

Safety Information

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GHS Pictogram : N/A	GHS No : N/A
Signal Word : N/A	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

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Computational Chemistry Data

TPSA 100.24
LogP -0.9039
H_Acceptors 6
H_Donors 2
Rotatable_Bonds 13

Other Classifications

Life Science PROTAC PROTAC Linker

Life Science Linker Amino PEG

Life Science Linker PEG Acid

Building Blocks Skeleton Fatty chain compounds

Life Science ADC Related Compound ADC Linker

Building Blocks Functional Group PEG

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Chemical Biology PEGylation Monofunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation Heterobifunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation PEG Oligomers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Biochemicals and Reagents Bioconjugation PEGylation Reagents and PEG Spacers

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Key Words

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Amino-PEG4-CH2COOH

CAS No. 195071-49-9

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