Lot numbers can be found on the outside label of a product:
Amino-PEG3-CH2COOH
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CAS No. 134978-99-7
- Cat. No. CS-0115122
- Purity≥96%
- MDL No.MFCD24479841
*For research and further manufacturing use only, not for direct human use.
Structure of 134978-99-7
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General Information
- CAS No. 134978-99-7
- Cat. No. CS-0115122
- Purity ≥96%
- MDL No. MFCD24479841
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₁₇NO₅
- Molecular Weight 207.22
- Synonym(s) None
- SMILES O=C(O)COCCOCCOCCN
Description
Amino-PEG3-CH2COOH is a bifunctional PEG-based linker featuring a primary amine at one terminus and a carboxylic acid at the other. This combination enables efficient conjugation to biomolecules via amide bond formation or coupling to activated esters, facilitating site-specific bioconjugation in protein labeling, drug delivery systems, and surface functionalization. The three-ethylene glycol repeat units provide enhanced solubility and reduced non-specific binding in aqueous environments.
Application
Amino-PEG3-CH2COOH serves as a versatile bifunctional linker for conjugation and polymer synthesis, combining the solubility and biocompatibility of PEG with reactive amine and carboxylic acid termini. The triethylene glycol spacer provides enhanced flexibility and hydrophilicity, while the terminal groups enable efficient coupling to biomolecules, surfaces, or resins via standard amide or NHS ester chemistry. This compound facilitates robust, site-specific functionalization in drug delivery systems, bioconjugates, and surface-modified materials.
Synthesis
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Route1
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In-stock
172531-37-2 - ~99%
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In-stock
134978-99-7
References
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Boumrah, Derradji; Campbell, Malcolm M.; Fenner, Simon; Kinsman, Richard G. Tetrahedron, 1997 , vol. 53, # 20 p. 6977 - 6992
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Route2
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In-stock
5197-62-6 - ~%
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In-stock
134978-99-7
References
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Boumrah, Deradji; Campbell, Malcolm M.; Fenner, Simon; Kinsman, Richard G. Tetrahedron Letters, 1991 , vol. 32, # 52 p. 7735 - 7738
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Route3
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118988-06-0 - ~%
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In-stock
134978-99-7
References
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Boumrah, Deradji; Campbell, Malcolm M.; Fenner, Simon; Kinsman, Richard G. Tetrahedron Letters, 1991 , vol. 32, # 52 p. 7735 - 7738
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H312-H332
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501
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Quality Control
Computational Chemistry Data
- TPSA 91.01
- LogP -0.9205
- H_Acceptors 5
- H_Donors 2
- Rotatable_Bonds 10
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Key Words
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