Lot numbers can be found on the outside label of a product:
tert-Butyl 3-acetylazetidine-1-carboxylate
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CAS No. 870089-49-9
- Cat. No. CS-0042839
- Purity≥95%
- MDL No.MFCD18073441
*For research and further manufacturing use only, not for direct human use.
Structure of 870089-49-9
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General Information
- CAS No. 870089-49-9
- Cat. No. CS-0042839
- Purity ≥95%
- MDL No. MFCD18073441
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₀H₁₇NO₃
- Molecular Weight 199.25
- Synonym(s) 1-Boc-3-acetyl-azetidine
- SMILES O=C(N1CC(C(C)=O)C1)OC(C)(C)C
Description
tert-Butyl 3-acetylazetidine-1-carboxylate features a sterically hindered azetidine core with a strategically positioned acetyl group, enabling direct functionalization at the nitrogen. This bench-stable, moisture-tolerant reagent integrates readily into synthetic sequences for medicinal chemistry and peptide derivatization. The tert-butyl ester facilitates selective deprotection under mild acidic conditions, streamlining access to functionalized azetidines.
Application
tert-Butyl 3-acetylazetidine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient access to azetidine-containing scaffolds. The acetyl group provides a handle for selective transformations, while the tert-butoxycarbonyl (Boc) protection ensures stability and ease of deprotection under mild acidic conditions. Its compatibility with standard coupling reactions and functional group tolerance makes it well-suited for iterative synthesis of complex heterocycles and API intermediates.
Synthesis
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Route1
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![tert-Butyl 3-[methoxy(methyl)carbamoyl]azetidine-1-carboxylate|CS-0048337](https://file.chemscene.com/productPIC/CS-0048337.gif)
820971-67-3 -
75-16-1 - ~93%
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In-stock
870089-49-9
References
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Pfizer Inc. Patent: US2010/190771 A1, 2010 ; Location in patent: Page/Page column 31-32 ;
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Route2
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1309208-79-4
- ~99%
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In-stock
870089-49-9
References
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FAB PHARMA SAS; GERUSZ, Vincent; ESCAICH, Sonia; OXOBY, Mayalen; DENIS, Alexis Patent: WO2011/61214 A1, 2011 ; Location in patent: Page/Page column 147-148 ; WO 2011/061214 A1
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Route3
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820971-67-3
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917-54-4
- ~%
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In-stock
870089-49-9
References
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Proskelia SAS Patent: US2008/58348 A1, 2008 ; Location in patent: Page/Page column 13 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 46.61
- LogP 1.4423
- H_Acceptors 3
- H_Donors 0
- Rotatable_Bonds 1
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Key Words
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