tert-Butyl 3-(1-hydroxyethyl)azetidine-1-carboxylate

Name: tert-Butyl 3-(1-hydroxyethyl)azetidine-1-carboxylate
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CAS No. 1138331-90-4
Cat. No. CS-0056889
Molecule weight201.26
Purity≥97%
MDL No.None

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tert-Butyl 3-(1-hydroxyethyl)azetidine-1-carboxylate|CS-0056889

Structure of 1138331-90-4

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General Information

CAS No. 1138331-90-4
Cat. No. CS-0056889
Purity ≥97%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₉NO₃
Molecular Weight 201.26
Synonym(s) 1-Boc-3-(1-hydroxyethyl)-azetidine
SMILES O=C(N1CC(C(O)C)C1)OC(C)(C)C

Description

tert-Butyl 3-(1-hydroxyethyl)azetidine-1-carboxylate features a strained azetidine core functionalized with a tertiary alcohol and a robust tert-butoxycarbonyl protecting group. This combination enables direct incorporation into complex scaffolds while maintaining stability under standard conditions, offering efficient access to bioactive nitrogen heterocycles in medicinal chemistry workflows.

Application

tert-Butyl 3-(1-hydroxyethyl)azetidine-1-carboxylate serves as a stable, bench-ready building block for the synthesis of bioactive azetidine-containing scaffolds. The pendant hydroxyl group enables straightforward derivatization via oxidation or protection, while the tert-butyl ester facilitates selective deprotection under mild acidic conditions. Its compatibility with standard coupling reactions and tolerance to diverse functional groups make it a practical choice for medicinal chemistry campaigns targeting constrained cyclic amines.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

TPSA 49.77
LogP 1.2341
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Alcohol

Building Blocks Skeleton Aliphatic heterocycle compounds Azetidine compounds

Key Words

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tert-Butyl 3-(1-hydroxyethyl)azetidine-1-carboxylate

CAS No. 1138331-90-4

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