2,4-Dichloro-5-methoxyquinazoline

Name: 2,4-Dichloro-5-methoxyquinazoline
Brand: ChemScene
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CAS No. 61948-59-2
Cat. No. CS-0019255
Molecule weight229.06
Purity≥98%
MDL No.MFCD10697887

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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2,4-Dichloro-5-methoxyquinazoline|CS-0019255

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General Information

CAS No. 61948-59-2
Cat. No. CS-0019255
Purity ≥98%
MDL No. MFCD10697887
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₆Cl₂N₂O
Molecular Weight 229.06
Synonym(s) Quinazoline, 2,4-dichloro-5-methoxy-
SMILES COC1=CC=CC2=NC(Cl)=NC(Cl)=C12

Description

2,4-Dichloro-5-methoxyquinazoline features a sterically hindered quinazoline core with orthogonal halogen and methoxy substituents, enabling selective cross-coupling in late-stage functionalization. This bench-stable scaffold integrates readily into kinase inhibitor architectures and serves as a robust building block for targeted covalent probe development under standard conditions.

Application

2,4-Dichloro-5-methoxyquinazoline serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. The dichloro substitution pattern facilitates sequential derivatization at C2 and C4 positions, while the methoxy group enhances solubility and modulates electronic properties. Its bench-stable nature and compatibility with diverse nucleophiles make it ideal for constructing quinazoline-based kinase inhibitors and other bioactive scaffolds.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 35.01
LogP 2.9452
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Quinazoline compounds

Key Words

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2,4-Dichloro-5-methoxyquinazoline

CAS No. 61948-59-2

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