Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

2,4-Dichloro-6-methoxyquinazoline

  • CAS No. 105763-77-7

  • Cat. No. CS-W003701
  • Purity≥95%
  • MDL No.MFCD09954880

*For research and further manufacturing use only, not for direct human use.

2,4-Dichloro-6-methoxyquinazoline|CS-W003701

Structure of 105763-77-7

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 105763-77-7
  • Cat. No. CS-W003701
  • Purity ≥95%
  • MDL No. MFCD09954880
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆Cl₂N₂O
  • Molecular Weight 229.06
  • Synonym(s) 6-Methoxy-2,4-dichloroquinazoline
  • SMILES COc1ccc2c(c1)c(Cl)nc(n2)Cl

Description

2,4-Dichloro-6-methoxyquinazoline features a halogenated quinazoline core with complementary electron-withdrawing chloro groups and a methoxy substituent. This combination enhances electrophilicity at the C7 position, enabling efficient coupling in palladium-catalyzed cross-coupling reactions. The compound exhibits excellent stability under standard bench conditions and serves as a key intermediate in kinase inhibitor synthesis.

Application

2,4-Dichloro-6-methoxyquinazoline serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. The dichloro substitution pattern facilitates sequential derivatization at C2 and C4 positions, while the methoxy group enhances solubility and modulates electronic properties. Its bench-stable crystalline form simplifies handling and purification, making it well-suited for high-throughput synthesis of quinazoline-based kinase inhibitors and other bioactive scaffolds.

Synthesis

  • Route1
    • 6-Methoxyquinazoline-2,4-diol|CS-0451052
      32618-84-1
    • ~81%
    • In-stock
      2,4-Dichloro-6-methoxyquinazoline|CS-W003701
      105763-77-7

    References

    • US2010/68197 A1, ; Page/Page column 17 ;
  • Route2
    • null|null
      32315-10-9
    • In-stock
      2-Amino-5-methoxybenzonitrile|CS-W005256
      23842-82-2
    • ~95%
    • In-stock
      2,4-Dichloro-6-methoxyquinazoline|CS-W003701
      105763-77-7

    References

    • Heterocycles, , vol. 85, # 6 p. 1417 - 1426
  • Route3

    References

    • US5688803 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   35.01
  • LogP   2.9452
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 2,4-Dichloro-6-methoxyquinazoline sigma2,4-Dichloro-6-methoxyquinazoline manufacturer2,4-Dichloro-6-methoxyquinazoline price2,4-Dichloro-6-methoxyquinazoline structure2,4-Dichloro-6-methoxyquinazoline SDSbuy 2,4-Dichloro-6-methoxyquinazoline2,4-Dichloro-6-methoxyquinazoline supplier2,4-Dichloro-6-methoxyquinazoline uses2,4-Dichloro-6-methoxyquinazoline molecular weightprice of 2,4-Dichloro-6-methoxyquinazoline2,4-Dichloro-6-methoxyquinazoline chemical name formula of 2,4-Dichloro-6-methoxyquinazoline
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label