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Structure of 61948-60-5
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2,4-Dichloro-8-methoxyquinazoline features a sterically accessible quinazoline core with electron-withdrawing chloro groups at positions 2 and 4, paired with a moisture-tolerant methoxy substituent at C8. This combination enables reliable coupling in late-stage functionalization, particularly within kinase inhibitor scaffolds and heterocyclic drug discovery workflows.
2,4-Dichloro-8-methoxyquinazoline serves as a versatile building block for the synthesis of kinase inhibitors and other bioactive heterocycles. The dichloro substitution enables selective nucleophilic aromatic substitution, while the methoxy group enhances solubility and modulates electronic properties. This compound functions effectively in Pd-catalyzed coupling reactions and facilitates access to substituted quinazolines under mild conditions, offering reliable performance in medicinal chemistry workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: