Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

2,4-Dichloro-8-methoxyquinazoline

  • CAS No. 61948-60-5

  • Cat. No. CS-W021511
  • Molecule weight229.06
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2,4-Dichloro-8-methoxyquinazoline|CS-W021511

Structure of 61948-60-5

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 61948-60-5
  • Cat. No. CS-W021511
  • Purity ≥95%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆Cl₂N₂O
  • Molecular Weight 229.06
  • Synonym(s) 8-Methoxy-2,4-dichloroquinazoline
  • SMILES COC1=CC=CC2=C(Cl)N=C(Cl)N=C12

Description

2,4-Dichloro-8-methoxyquinazoline features a sterically accessible quinazoline core with electron-withdrawing chloro groups at positions 2 and 4, paired with a moisture-tolerant methoxy substituent at C8. This combination enables reliable coupling in late-stage functionalization, particularly within kinase inhibitor scaffolds and heterocyclic drug discovery workflows.

Application

2,4-Dichloro-8-methoxyquinazoline serves as a versatile building block for the synthesis of kinase inhibitors and other bioactive heterocycles. The dichloro substitution enables selective nucleophilic aromatic substitution, while the methoxy group enhances solubility and modulates electronic properties. This compound functions effectively in Pd-catalyzed coupling reactions and facilitates access to substituted quinazolines under mild conditions, offering reliable performance in medicinal chemistry workflows.

Synthesis

  • Route1

    References

    • Journal of Medicinal Chemistry, , vol. 38, # 14 p. 2763 - 2773
  • Route2

    References

    • Journal of Medicinal Chemistry, , vol. 38, # 14 p. 2763 - 2773
  • Route3

    References

    • US5686458 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   35.01
  • LogP   2.9452
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 2,4-Dichloro-8-methoxyquinazoline sigma2,4-Dichloro-8-methoxyquinazoline manufacturer2,4-Dichloro-8-methoxyquinazoline price2,4-Dichloro-8-methoxyquinazoline structure2,4-Dichloro-8-methoxyquinazoline SDSbuy 2,4-Dichloro-8-methoxyquinazoline2,4-Dichloro-8-methoxyquinazoline supplier2,4-Dichloro-8-methoxyquinazoline uses2,4-Dichloro-8-methoxyquinazoline molecular weightprice of 2,4-Dichloro-8-methoxyquinazoline2,4-Dichloro-8-methoxyquinazoline chemical name formula of 2,4-Dichloro-8-methoxyquinazoline
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label