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CS-W001157 4
Total: USD 88.00

6-Chloronicotinic acid

  • CAS No. 5326-23-8

  • Cat. No. CS-D1204
  • Purity≥96%
  • MDL No.MFCD00006241

*For research and further manufacturing use only, not for direct human use.

6-Chloronicotinic acid|CS-D1204

Structure of 5326-23-8

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General Information

  • CAS No. 5326-23-8
  • Cat. No. CS-D1204
  • Purity ≥96%
  • MDL No. MFCD00006241
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄ClNO₂
  • Molecular Weight 157.55
  • Synonym(s) 6-Chloropyridine-3-carboxylic acid; 6-Chloronicotinic acid
  • SMILES O=C(C1=CC=C(Cl)N=C1)O

Description

6-Chloropyridine-3-carboxylic acid (6-chloronicotinic acid/6-CNA) has been used to study its photolytic and photocatalytic degradation. 6-CNA is a degradation product of neonicotinoid insecticides imidacloprid and acetamiprid and is known to appear in different environmental matrices. The product has been used as a media component during the isolation of 6-CNA degrading bacterial strain from imidacloprid-exposed soil samples.

Application

6-Chloronicotinic acid serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct incorporation of a chlorine-substituted pyridine moiety. Its carboxylic acid functionality facilitates amide coupling, esterification, and metal-catalyzed transformations under standard conditions. The ortho-chloro substituent enhances electrophilic reactivity and provides a handle for cross-coupling reactions, while the molecule exhibits excellent bench stability and ease of purification—making it well-suited for high-throughput screening campaigns and process-scale applications.

Synthesis

  • Route1

    References

    • Ishihara Sangyo Kaisha Ltd. Patent: US4504665 A1, 1985 ;
  • Route2

    References

    • Wang, Qing Min; Sun, Hui Kai; Huang, Run Qiu Heteroatom Chemistry, 2004 , vol. 15, # 1 p. 67 - 70
  • Route3
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    • In-stock
      6-Chloronicotinic acid|CS-D1204
      5326-23-8

    References

    • Pest Management Science, , vol. 56, # 10 p. 932 - 936

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.4332
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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