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CS-W001157 4
Total: USD 88.00

4-Chloronicotinic acid

  • CAS No. 10177-29-4

  • Cat. No. CS-D1685
  • Purity≥98%
  • MDL No.MFCD00128860

*For research and further manufacturing use only, not for direct human use.

4-Chloronicotinic acid|CS-D1685

Structure of 10177-29-4

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General Information

  • CAS No. 10177-29-4
  • Cat. No. CS-D1685
  • Purity ≥98%
  • MDL No. MFCD00128860
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄ClNO₂
  • Molecular Weight 157.55
  • Synonym(s) Nicotinic acid, 4-chloro-; 4-Chloro-3-pyridinecarboxylic acid; IFLAB-BB F1926-0029; 4-Chloronicotinic acid
  • SMILES O=C(C1=C(Cl)C=CN=C1)O

Description

ARV-825 is a PROTAC molecule composed of a BRD4 binding moiety joined to an E3 ligase cereblon binding moiety. ARV-825 recruits BRD4 to E3 ubiquitin ligase cereblon, resulting in the degradation of BRD4.

Synthesis

  • Route1
    • null|null
      124-38-9
    • ~60%
    • In-stock
      4-Chloronicotinic acid|CS-D1685
      10177-29-4

    References

    • WO2008/24724 A1, ; Page/Page column 63 ; WO 2008/024724 A1
  • Route2
    • null|null
      124-38-9
    • In-stock
      4-Chloropyridine hydrochloride|CS-W019791
      7379-35-3
    • ~55%
    • In-stock
      4-Chloronicotinic acid|CS-D1685
      10177-29-4

    References

    • WO2011/58149 A1, ; Page/Page column 123-124 ; WO 2011/058149 A1
  • Route3
    • 4-Chloropyridine|CS-0139547
      626-61-9
    • null|null
      124-38-9
    • ~96%
    • In-stock
      4-Chloronicotinic acid|CS-D1685
      10177-29-4

    References

    • Journal of Organic Chemistry, , vol. 60, # 2 p. 292 - 296

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H319-H402
Precautionary Statements : P264-P273-P280-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.4332
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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