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CS-W001157 4
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4-Chloropyridine hydrochloride

  • CAS No. 7379-35-3

  • Cat. No. CS-W019791
  • Purity≥98%
  • MDL No.MFCD00012829

*For research and further manufacturing use only, not for direct human use.

4-Chloropyridine hydrochloride|CS-W019791

Structure of 7379-35-3

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General Information

  • CAS No. 7379-35-3
  • Cat. No. CS-W019791
  • Purity ≥98%
  • MDL No. MFCD00012829
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅Cl₂N
  • Molecular Weight 150.01
  • Synonym(s) None
  • SMILES ClC1=CC=NC=C1.[H]Cl

Description

4-Chloropyridine (hydrochloride) offers a stable, moisture-tolerant platform for pyridine-based synthesis. The protonated nitrogen enhances electrophilic reactivity, while the para-chloro substituent enables direct functionalization via cross-coupling or nucleophilic substitution. This salt form improves solubility in polar solvents and simplifies handling under standard bench conditions.

Application

4-Chloropyridine (hydrochloride) serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient nucleophilic substitution reactions at the pyridine C4 position. Its protonated form enhances solubility and stability in aqueous and polar organic media, facilitating handling and purification. The chloride functionality permits reliable coupling with amines, thiols, and organometallic reagents, supporting the construction of heterocyclic scaffolds and functionalized intermediates under standard reaction conditions.

Synthesis

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    • In-stock
      4-Chloropyridine hydrochloride|CS-W019791
      7379-35-3

    References

    • Chemische Berichte, , vol. 32, p. 1309

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P264-P270-P280-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.1568
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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