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CS-W001157 4
Total: USD 88.00

4-Chloroquinazoline

  • CAS No. 5190-68-1

  • Cat. No. CS-W013243
  • Purity≥97%
  • MDL No.MFCD00228682

*For research and further manufacturing use only, not for direct human use.

4-Chloroquinazoline|CS-W013243

Structure of 5190-68-1

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General Information

  • CAS No. 5190-68-1
  • Cat. No. CS-W013243
  • Purity ≥97%
  • MDL No. MFCD00228682
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅ClN₂
  • Molecular Weight 164.59
  • Synonym(s) 4-Chloro-quizoline; 4-Chloroquinazoline
  • SMILES ClC1=C2C=CC=CC2=NC=N1

Description

4-Chloroquinazoline is a bench-stable, electron-deficient heterocycle serving as a key scaffold in medicinal chemistry. This fused bicyclic system integrates readily into kinase inhibitor designs and other bioactive molecules, offering enhanced binding affinity through its polarizable π-framework and reactive chlorine site for downstream functionalization.

Synthesis

  • Route1

    References

    • Eisai Co., Ltd. Patent: EP1669348 A1, 2006 ; Location in patent: Page/Page column 75 ;
  • Route2
    • null|null
      13182-59-7
    • ~99%
    • In-stock
      4-Chloroquinazoline|CS-W013243
      5190-68-1

    References

    • Ham, Young Jin; Lee, Duck-Hyung; Choi, Hwan Geun; Hah, Jung-Mi; Sim, Taebo Tetrahedron Letters, 2010 , vol. 51, # 35 p. 4609 - 4611
  • Route3
    • 4-(Phenylthio)quinazoline|CS-1693841
      6344-76-9
    • ~79%
    • In-stock
      4-Chloroquinazoline|CS-W013243
      5190-68-1

    References

    • Ham, Young Jin; Lee, Duck-Hyung; Choi, Hwan Geun; Hah, Jung-Mi; Sim, Taebo Tetrahedron Letters, 2010 , vol. 51, # 35 p. 4609 - 4611

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   2.2832
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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