2,4-Dichloro-7-fluoro-6-methoxyquinazoline

Name: 2,4-Dichloro-7-fluoro-6-methoxyquinazoline
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 864292-37-5
Cat. No. CS-0053726
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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*For research and further manufacturing use only, not for direct human use.

2,4-Dichloro-7-fluoro-6-methoxyquinazoline|CS-0053726

Structure of 864292-37-5

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General Information

CAS No. 864292-37-5
Cat. No. CS-0053726
Purity ≥97%
MDL No. None
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₅Cl₂FN₂O
Molecular Weight 247.05
Synonym(s) 2,4-Dichloro-7-fluoro-6-Methoxy-quinazoline
SMILES COC1=CC2=C(Cl)N=C(Cl)N=C2C=C1F

Description

2,4-Dichloro-7-fluoro-6-methoxyquinazoline features a highly functionalized quinazoline core with orthogonal reactivity enabled by chlorine, fluorine, and methoxy substituents. This electron-deficient scaffold integrates readily into pharmaceutical intermediates, offering robust stability under standard conditions and compatibility with palladium-catalyzed coupling reactions.

Application

2,4-Dichloro-7-fluoro-6-methoxyquinazoline serves as a versatile building block in medicinal chemistry, enabling efficient construction of quinazoline-based scaffolds. Its electrophilic chlorine and fluorine substituents facilitate nucleophilic substitution reactions under mild conditions, while the methoxy group enhances solubility and modulates electronic properties. The compound exhibits excellent bench stability and is compatible with standard coupling protocols, making it ideal for the synthesis of kinase inhibitors and other bioactive heterocycles.

Synthesis

Route1
- 769158-25-0
- ~%
- In-stock
  
  864292-37-5
References
- Feng, Jun; Zhang, Zhiyuan; Wallace, Michael B.; Stafford, Jeffrey A.; Kaldor, Stephen W.; Kassel, Daniel B.; Navre, Marc; Shi, Lihong; Skene, Robert J.; Asakawa, Tomoko; Takeuchi, Koji; Xu, Rongda; Webb, David R.; Gwaltney II, Stephen L. Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2297 - 2300
Route2
- In-stock
  
  159768-51-1
- ~%
- In-stock
  
  864292-37-5
References
- Feng, Jun; Zhang, Zhiyuan; Wallace, Michael B.; Stafford, Jeffrey A.; Kaldor, Stephen W.; Kassel, Daniel B.; Navre, Marc; Shi, Lihong; Skene, Robert J.; Asakawa, Tomoko; Takeuchi, Koji; Xu, Rongda; Webb, David R.; Gwaltney II, Stephen L. Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2297 - 2300

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 35.01
LogP 3.0843
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Quinazoline compounds

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2,4-Dichloro-7-fluoro-6-methoxyquinazoline

CAS No. 864292-37-5

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