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CS-W001157 4
Total: USD 88.00

4-(Phenylsulfanyl)benzaldehyde

  • CAS No. 1208-88-4

  • Cat. No. CS-0116840
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-(Phenylsulfanyl)benzaldehyde|CS-0116840

Structure of 1208-88-4

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General Information

  • CAS No. 1208-88-4
  • Cat. No. CS-0116840
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₀OS
  • Molecular Weight 214.28
  • Synonym(s) 4-(Phenylthio)benzaldehyde
  • SMILES O=CC1=CC=C(SC2=CC=CC=C2)C=C1

Description

4-(Phenylsulfanyl)benzaldehyde features a benzaldehyde core linked to a phenylthio group at the para position, delivering a robust scaffold for transition metal-catalyzed cross-coupling reactions. This electron-rich aryl thioether exhibits excellent stability under standard conditions and integrates readily into complex molecular architectures requiring orthogonal functional handles.

Application

4-(Phenylsulfanyl)benzaldehyde serves as a versatile building block in synthetic organic chemistry, enabling the construction of biaryl and heterocyclic scaffolds through palladium-catalyzed cross-coupling reactions. The phenylthio group exhibits good stability under standard reaction conditions while permitting selective transformation, and the aldehyde functionality facilitates subsequent derivatization via nucleophilic addition or condensation reactions. Its robust bench stability and compatibility with diverse functional groups make it well-suited for applications in medicinal chemistry and materials science.

Synthesis

  • Route1
    • In-stock
      4-Chlorobenzaldehyde|CS-W008778
      104-88-1
    • null|null
      108-98-5
    • ~96%
    • In-stock
      4-(Phenylsulfanyl)benzaldehyde|CS-0116840
      1208-88-4

    References

    • Zhang, Xin-Yan; Zhang, Xiao-Yan; Guo, Sheng-Rong Journal of Sulfur Chemistry, 2011 , vol. 32, # 1 p. 23 - 35
  • Route2
    • p-Fluorobenzenecarboxaldehyde Atorvastatin calcium|CS-0214005
      459-57-4
    • null|null
      108-98-5
    • ~99%
    • In-stock
      4-(Phenylsulfanyl)benzaldehyde|CS-0116840
      1208-88-4

    References

    • Tanaka, Akira; Terasawa, Takeshi; Hagihara, Hiroyuki; Sakuma, Yuri; Ishibe, Noriko; Sawada, Masae; Takasugi, Hisashi; Tanaka, Hirokazu Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 1 p. 15 - 30
  • Route3

    References

    • Yu, Xiao-Chun; Li, Bo; Yu, Bao-Hua; Xu, Qing Chinese Chemical Letters, 2013 , vol. 24, # 7 p. 605 - 608

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H228
Precautionary Statements : P210-P240-P241-P280-P370+P378

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   3.6503
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   3

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