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CS-W001157 4
Total: USD 88.00

2,4-Dichloro-7-methoxyquinazoline

  • CAS No. 62484-31-5

  • Cat. No. CS-W019059
  • Purity≥97%
  • MDL No.MFCD09954881

*For research and further manufacturing use only, not for direct human use.

2,4-Dichloro-7-methoxyquinazoline|CS-W019059

Structure of 62484-31-5

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General Information

  • CAS No. 62484-31-5
  • Cat. No. CS-W019059
  • Purity ≥97%
  • MDL No. MFCD09954881
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆Cl₂N₂O
  • Molecular Weight 229.06
  • Synonym(s) T66 BN DNJ CG EG IO1
  • SMILES ClC2=NC1=CC(=CC=C1C(=N2)Cl)OC

Description

2,4-Dichloro-7-methoxyquinazoline features a sterically accessible quinazoline core with electron-withdrawing chloro groups at positions 2 and 4, paired with a methoxy substituent at C7. This combination enhances electrophilicity for nucleophilic substitution and improves solubility in polar organic media. The compound serves as a key scaffold in kinase inhibitor development and is compatible with standard coupling protocols under mild conditions.

Application

2,4-Dichloro-7-methoxyquinazoline serves as a versatile building block in medicinal chemistry, enabling efficient construction of quinazoline-based scaffolds. The dichloro substitution pattern facilitates sequential nucleophilic aromatic substitution, allowing selective introduction of diverse amine and heterocyclic moieties. Its methoxy group enhances solubility and modulates electronic properties, while the compound exhibits excellent bench stability and ease of purification—key advantages for high-throughput synthesis and process development.

Synthesis

  • Route1

    References

    • Tetrahedron Letters, , vol. 49, # 42 p. 6081 - 6083
  • Route2
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    • In-stock
      2,4-Dichloro-7-methoxyquinazoline|CS-W019059
      62484-31-5

    References

    • Journal of the Chemical Society, , p. 890,894
  • Route3

    References

    • Journal of the Chemical Society, , p. 890,894

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   35.01
  • LogP   2.9452
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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