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CS-W001157 4
Total: USD 88.00

4-Chloro-5,7-dimethoxyquinazoline

  • CAS No. 884340-91-4

  • Cat. No. CS-0172647
  • Molecule weight224.64
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Chloro-5,7-dimethoxyquinazoline|CS-0172647

Structure of 884340-91-4

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General Information

  • CAS No. 884340-91-4
  • Cat. No. CS-0172647
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₉ClN₂O₂
  • Molecular Weight 224.64
  • Synonym(s) 4-chloro-5,7-dimethoxy-quinazoline
  • SMILES COC1=CC2=C(C(=C1)OC)C(=NC=N2)Cl

Synthesis

  • Route1
    • 5,7-Dimethoxyquinazolin-4-ol|CS-0172648
      379228-27-0
    • ~53%
    • 4-Chloro-5,7-dimethoxyquinazoline|CS-0172647
      884340-91-4

    References

    • ASTRAZENECA AB; ASTRAZENECA UK LIMITED Patent: WO2006/67391 A1, 2006 ; Location in patent: Page/Page column 49-50 ; WO 2006/067391 A1
  • Route2

    References

    • Hennequin, Laurent F.; Allen, Jack; Breed, Jason; Curwen, Jon; Fennell, Michael; Green, Tim P.; Lambert-Van Der Brempt, Christine; Morgentin, Remy; Norman, Richard A.; Olivier, Annie; Otterbein, Ludovic; Ple, Patrick A.; Warin, Nicolas; Costello, Gerard Journal of Medicinal Chemistry, 2006 , vol. 49, # 22 p. 6465 - 6488
  • Route3
    • Methyl 2-amino-4,6-dimethoxybenzoate|CS-0150504
      379228-26-9
    • ~%
    • 4-Chloro-5,7-dimethoxyquinazoline|CS-0172647
      884340-91-4

    References

    • Hennequin, Laurent F.; Allen, Jack; Breed, Jason; Curwen, Jon; Fennell, Michael; Green, Tim P.; Lambert-Van Der Brempt, Christine; Morgentin, Remy; Norman, Richard A.; Olivier, Annie; Otterbein, Ludovic; Ple, Patrick A.; Warin, Nicolas; Costello, Gerard Journal of Medicinal Chemistry, 2006 , vol. 49, # 22 p. 6465 - 6488

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   44.24
  • LogP   2.3004
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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