(R)-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride

Name: (R)-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride
Brand: ChemScene
Availability: InStock
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CAS No. 58349-15-8
Cat. No. CS-M1341
Molecule weight213.70
Purity≥97%
MDL No.None

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(R)-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride|CS-M1341

Structure of 58349-15-8

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General Information

CAS No. 58349-15-8
Cat. No. CS-M1341
Purity ≥97%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₁₆ClNO
Molecular Weight 213.70
Synonym(s) (R)-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine (Hydrochloride)
SMILES N[C@H]1CC2=C(C(OC)=CC=C2)CC1.Cl

Description

(R)-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride is a chiral amine scaffold featuring a methoxy-substituted tetralin core. This bench-stable derivative integrates readily into asymmetric synthesis workflows, offering predictable stereochemical control in medicinal chemistry applications.

Application

(R)-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride serves as a stereochemically defined building block for medicinal chemistry applications, enabling access to chiral tetralin scaffolds prevalent in CNS-targeted therapeutics. The hydrochloride salt enhances solubility and stability, facilitating straightforward handling and purification. It functions effectively in amine coupling reactions and supports diverse functionalization at the aromatic ring, making it suitable for parallel synthesis campaigns and structure-activity relationship studies.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 35.25
LogP 1.933
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(R)-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride

CAS No. 58349-15-8

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