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CS-W001157 4
Total: USD 88.00

4-(4-Chlorophenoxy)benzaldehyde

  • CAS No. 61343-99-5

  • Cat. No. CS-0038685
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-(4-Chlorophenoxy)benzaldehyde|CS-0038685

Structure of 61343-99-5

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General Information

  • CAS No. 61343-99-5
  • Cat. No. CS-0038685
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₉ClO₂
  • Molecular Weight 232.66
  • Synonym(s) 4-Chloro-4-Formyldiphenyl Ether
  • SMILES C1=C(C=CC(=C1)OC2=CC=C(C=C2)Cl)C=O

Description

4-(4-Chlorophenoxy)benzaldehyde features a para-chlorophenoxy linker fused to an aromatic aldehyde, delivering enhanced solubility and stability in polar organic solvents. This electron-deficient aryl aldehyde integrates readily into Suzuki-Miyaura coupling cascades and serves as a key intermediate in the synthesis of bioactive heterocycles and fluorescent probes.

Application

4-(4-Chlorophenoxy)benzaldehyde serves as a versatile building block in medicinal and agrochemical synthesis, enabling efficient construction of biaryl and heterocyclic scaffolds. Its aldehyde functionality facilitates reductive amination, Ullmann coupling, and Grignard additions, while the chlorophenoxy group offers orthogonal reactivity and enhanced metabolic stability. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step sequences requiring functional group tolerance and structural precision.

Synthesis

  • Route1
    • p-Fluorobenzenecarboxaldehyde Atorvastatin calcium|CS-0214005
      459-57-4
    • null|null
      106-48-9
    • ~96%
    • In-stock
      4-(4-Chlorophenoxy)benzaldehyde|CS-0038685
      61343-99-5

    References

    • Matijssen, Cornelis; Silva-Santisteban, M. Cris; Westwood, Isaac M.; Siddique, Samerene; Choi, Vanessa; Sheldrake, Peter; Van Montfort, Rob L.M.; Blagg, Julian Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 22 p. 6630 - 6639
  • Route2
    • In-stock
      4-Nitrobenzaldehyde|CS-W007577
      555-16-8
    • null|null
      106-48-9
    • ~88%
    • In-stock
      4-(4-Chlorophenoxy)benzaldehyde|CS-0038685
      61343-99-5

    References

    • Wang, Hailei; Yu, Ajuan; Cao, Aijuan; Chang, Junbiao; Wu, Yangjie Applied Organometallic Chemistry, 2013 , vol. 27, # 10 p. 611 - 614
  • Route3

    References

    • Zheng, Xingwang; Ding, Jinchang; Chen, Jiuxi; Gao, Wenxiao; Liu, Miaochang; Wu, Huayue Organic Letters, 2011 , vol. 13, # 7 p. 1726 - 1729

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   3.9448
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   3

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