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CS-W001157 4
Total: USD 88.00

1-Methyl-4-(methylamino)piperidine

  • CAS No. 73579-08-5

  • Cat. No. CS-W002005
  • Purity≥95%
  • MDL No.MFCD00006498

*For research and further manufacturing use only, not for direct human use.

1-Methyl-4-(methylamino)piperidine|CS-W002005

Structure of 73579-08-5

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General Information

  • CAS No. 73579-08-5
  • Cat. No. CS-W002005
  • Purity ≥95%
  • MDL No. MFCD00006498
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₆N₂
  • Molecular Weight 128.22
  • Synonym(s) N,1-dimethylpiperidin-4-amine
  • SMILES CNC1CCN(CC1)C

Description

1-Methyl-4-(methylamino)piperidine is a tertiary amine featuring a piperidine core with methyl and methylamino substituents at the 1- and 4-positions, respectively. This configuration imparts strong basicity and enhanced solubility in organic solvents. The compound serves as a key building block in medicinal chemistry, particularly for constructing bioactive molecules with improved metabolic stability and membrane permeability.

Application

1-Methyl-4-(methylamino)piperidine serves as a versatile nitrogen-containing scaffold in medicinal chemistry, enabling efficient construction of bioactive heterocycles. Its tertiary amine functionality offers favorable solubility and metabolic stability, while the piperidine core facilitates diverse functionalization through standard alkylation and coupling reactions. The molecule demonstrates robust bench stability and compatibility with common purification methods, making it a practical building block for lead optimization and API synthesis.

Synthesis

  • Route1
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    • In-stock
      1-Methyl-4-(methylamino)piperidine|CS-W002005
      73579-08-5

    References

    • Journal of the Chemical Society, , p. 3165,3171
  • Route2
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      1445-73-4
    • ~%
    • In-stock
      1-Methyl-4-(methylamino)piperidine|CS-W002005
      73579-08-5

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 1 p. 347 - 352

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS05
Signal Word : Danger
UN#: 2920
Class : 8,3
Packing Group : Ⅱ
Hazard Statements : H225-H314
Precautionary Statements : P210-P233-P240-P241-P242-P243-P260-P264-P280-P301+P330+P331-P304+P340-P363-P370+P378-P405-P501

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Computational Chemistry Data

  • TPSA   15.27
  • LogP   0.3
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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