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CS-W001157 4
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N,N-Dimethylpiperidin-4-amine

  • CAS No. 50533-97-6

  • Cat. No. CS-W002131
  • Purity≥98%
  • MDL No.MFCD00023144

*For research and further manufacturing use only, not for direct human use.

N,N-Dimethylpiperidin-4-amine|CS-W002131

Structure of 50533-97-6

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General Information

  • CAS No. 50533-97-6
  • Cat. No. CS-W002131
  • Purity ≥98%
  • MDL No. MFCD00023144
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₆N₂
  • Molecular Weight 128.22
  • Synonym(s) 4-dimethylaminopiperidine
  • SMILES CN(C)C1CCNCC1

Description

N,N-Dimethylpiperidin-4-amine features a tertiary amine center within a piperidine ring, delivering strong nucleophilicity and solubility in polar solvents. This bench-stable compound integrates readily into synthetic workflows, serving as a catalytic base or functional handle in medicinal chemistry and polymer synthesis.

Application

N,N-Dimethylpiperidin-4-amine serves as a versatile nitrogen-containing building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds and amine-functionalized intermediates. Its tertiary amine functionality offers enhanced solubility and basicity, facilitating coupling reactions and salt formation. The piperidine core provides conformational stability and favorable pharmacokinetic properties, making it a valuable component in the synthesis of bioactive molecules and API precursors.

Synthesis

  • Route1
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      79099-07-3
    • ~%
    • In-stock
      N,N-Dimethylpiperidin-4-amine|CS-W002131
      50533-97-6

    References

    • van Duzer, John H.; Michaelis, Arthur F.; Geiss, William B.; Stafford, Douglas G.; Raker, Joseph; Yu, Xiang Y.; Siedlecki, James M.; Yang, Yingfei Patent: US2005/197333 A1, 2005 ; Location in patent: Page/Page column 33 ;
  • Route2
    • 1-Benzyl-4-(dimethylamino)piperidine|CS-0151303
      64168-08-7
    • ~%
    • In-stock
      N,N-Dimethylpiperidin-4-amine|CS-W002131
      50533-97-6

    References

    • SmithKline Corporation Patent: US3980788 A1, 1976 ;
  • Route3
    • N,N-Dimethylpyridin-4-amine Vonoprazan Impurity|CS-0167023
      1122-58-3
    • ~%
    • In-stock
      N,N-Dimethylpiperidin-4-amine|CS-W002131
      50533-97-6

    References

    • Cui, Yi; Kwok, Samantha; Bucholtz, Andrew; Davis, Boyd; Whitney, Ralph A.; Jessop, Philip G. New Journal of Chemistry, 2008 , vol. 32, # 6 p. 1027 - 1037

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302+H312+H332-H315-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   15.27
  • LogP   0.3
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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