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Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

1-Cyclopropylpiperazine

  • CAS No. 20327-23-5

  • Cat. No. CS-W008811
  • Purity≥97%
  • MDL No.MFCD06254805

*For research and further manufacturing use only, not for direct human use.

1-Cyclopropylpiperazine|CS-W008811

Structure of 20327-23-5

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General Information

  • CAS No. 20327-23-5
  • Cat. No. CS-W008811
  • Purity ≥97%
  • MDL No. MFCD06254805
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₄N₂
  • Molecular Weight 126.20
  • Synonym(s) None
  • SMILES N1(C2CC2)CCNCC1

Description

1-Cyclopropylpiperazine is a sterically constrained piperazine derivative featuring a cyclopropyl group at the N1 position. This substitution imparts enhanced metabolic stability and modulates basicity compared to unsubstituted piperazine. The molecule integrates readily into medicinal chemistry scaffolds, where its rigid, electron-rich framework supports target engagement in CNS-directed therapeutics and kinase inhibitors.

Synthesis

  • Route1
    • tert-Butyl 4-cyclopropylpiperazine-1-carboxylate|CS-0671720
      77278-34-3
    • ~59%
    • In-stock
      1-Cyclopropylpiperazine|CS-W008811
      20327-23-5

    References

    • US2008/153812 A1, ; Page/Page column 117 ; US 20080153812 A1
  • Route2
    • null|null
      110694-10-5
    • null|null
      765-30-0
    • ~%
    • In-stock
      1-Cyclopropylpiperazine|CS-W008811
      20327-23-5

    References

    • WO2008/76685 A2, ; Page/Page column 61 ; WO 2008/076685 A2
  • Route3
    • null|null
      159974-45-5
    • ~%
    • In-stock
      1-Cyclopropylpiperazine|CS-W008811
      20327-23-5

    References

    • Tetrahedron Letters, , vol. 35, # 40 p. 7331 - 7334

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3267
Class : 8
Packing Group : Ⅲ
Hazard Statements : H227-H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   15.27
  • LogP   0.054
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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