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CS-W001157 4
Total: USD 88.00

1-(Oxetan-3-yl)piperazine

  • CAS No. 1254115-23-5

  • Cat. No. CS-W007243
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(Oxetan-3-yl)piperazine|CS-W007243

Structure of 1254115-23-5

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General Information

  • CAS No. 1254115-23-5
  • Cat. No. CS-W007243
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₄N₂O
  • Molecular Weight 142.20
  • Synonym(s) None
  • SMILES N1(C2COC2)CCNCC1

Description

1-(Oxetan-3-yl)piperazine is a bench-stable, moisture-tolerant heterocyclic amine featuring a strained oxetane ring that enhances reactivity in bioconjugation and medicinal chemistry. This piperazine derivative integrates readily into drug candidates, where the oxetane moiety improves solubility and metabolic stability. The molecule's polar yet lipophilic character supports efficient membrane permeability and enables rapid coupling under mild conditions.

Application

1-(Oxetan-3-yl)piperazine serves as a valuable synthetic building block in medicinal chemistry, enabling the introduction of a strained, metabolically stable oxetane ring to enhance solubility and bioavailability. Its piperazine core provides versatile sites for functionalization, while the oxetanyl group exhibits excellent tolerance to diverse reaction conditions and facilitates favorable physicochemical properties in drug candidates. The compound is bench-stable and readily incorporated into standard coupling and cyclization protocols.

Synthesis

  • Route1
    • Benzyl 4-(oxetan-3-yl)piperazine-1-carboxylate|CS-0037001
      1254115-22-4
    • ~%
    • In-stock
      1-(Oxetan-3-yl)piperazine|CS-W007243
      1254115-23-5

    References

    • SANOFI Patent: US2012/277205 A1, 2012 ; Location in patent: Page/Page column 31-32 ; US 20120277205 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   24.5
  • LogP   -0.7096
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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