N-Methylpiperidine-3-carboxamide hydrochloride

Name: N-Methylpiperidine-3-carboxamide hydrochloride
Brand: ChemScene
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CAS No. 475060-42-5
Cat. No. CS-0094687
Purity≥97%
MDL No.MFCD09064923

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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N-Methylpiperidine-3-carboxamide hydrochloride|CS-0094687

Structure of 475060-42-5

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General Information

CAS No. 475060-42-5
Cat. No. CS-0094687
Purity ≥97%
MDL No. MFCD09064923
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₁₅ClN₂O
Molecular Weight 178.66
Synonym(s) N-Methyl-3-piperidinecarboxamide hydrochloride
SMILES O=C(C1CNCCC1)NC.[H]Cl

Description

N-Methylpiperidine-3-carboxamide hydrochloride delivers a rigid, electron-rich piperidine scaffold with a strategically positioned amide and methylated nitrogen. This combination enhances solubility and metabolic stability while maintaining favorable conformational restraint for target engagement in medicinal chemistry applications.

Application

N-Methylpiperidine-3-carboxamide hydrochloride serves as a versatile building block in medicinal chemistry, enabling efficient construction of bioactive heterocycles and peptide-like scaffolds. Its amide functionality offers enhanced metabolic stability and improved membrane permeability compared to parent amides. The piperidine core provides a rigid, conformationally constrained scaffold with favorable pharmacokinetic properties. Bench-stable and readily purified by recrystallization or ion-exchange chromatography, it functions effectively in standard coupling reactions and transition-metal-catalyzed transformations.

Synthesis

Route1
- 885698-91-9
- ~%
- In-stock
  
  475060-42-5
References
- PIRAMED LIMITED Patent: WO2006/46031 A1, 2006 ; Location in patent: Page/Page column 73-74 ; WO 2006/046031 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 41.13
LogP 0.1538
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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N-Methylpiperidine-3-carboxamide hydrochloride

CAS No. 475060-42-5

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