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CS-W001157 4
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2-Methoxy-4-morpholinoaniline

  • CAS No. 209960-91-8

  • Cat. No. CS-0147956
  • Purity≥95%
  • MDL No.MFCD09972210

*For research and further manufacturing use only, not for direct human use.

2-Methoxy-4-morpholinoaniline|CS-0147956

Structure of 209960-91-8

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General Information

  • CAS No. 209960-91-8
  • Cat. No. CS-0147956
  • Purity ≥95%
  • MDL No. MFCD09972210
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₆N₂O₂
  • Molecular Weight 208.26
  • Synonym(s) 2-Methoxy-4-morpholinobenzenamine
  • SMILES NC1=CC=C(N2CCOCC2)C=C1OC

Description

2-Methoxy-4-morpholinoaniline features a morpholino group that enhances solubility and electron-donating capacity, while the methoxy substituent stabilizes the aromatic system. This combination enables efficient coupling in amide bond formation and facilitates incorporation into complex molecular architectures under standard conditions.

Application

2-Methoxy-4-morpholinoaniline serves as a versatile building block in medicinal chemistry, enabling the synthesis of diverse heterocyclic scaffolds and bioactive compounds. Its ortho-methoxy and para-morpholino substituents provide complementary reactivity for coupling reactions and facilitate solubility and metabolic stability in target molecules. The compound exhibits good bench stability and is readily amenable to standard functional group transformations, making it a practical choice for lead optimization campaigns.

Synthesis

  • Route1

    References

    • CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; CHENG, Liang; LIU, Xijie; HU, Yuandong; XU, Xinhe; LIU, Zhihua; ZHANG, Lipeng; WU, Wei; WANG, Shulong; SHEN, Yu; LI, Gen; WANG, Yin; ZHAO, Sheng; LI, Chonglong; TANG, Jia; YU, Honghao Patent: WO2012/92880 A1, 2012 ; Location in patent: Page/Page column 49 ; WO 2012/092880 A1
  • Route2

    References

    • WO2012/45195 A1, ; WO 2012/045195 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   47.72
  • LogP   1.114
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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