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CS-W001157 4
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2-Methoxy-4-(4-methylpiperazin-1-yl)aniline

  • CAS No. 122833-04-9

  • Cat. No. CS-M2488
  • Purity≥96%
  • MDL No.MFCD11848954

*For research and further manufacturing use only, not for direct human use.

2-Methoxy-4-(4-methylpiperazin-1-yl)aniline|CS-M2488

Structure of 122833-04-9

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General Information

  • CAS No. 122833-04-9
  • Cat. No. CS-M2488
  • Purity ≥96%
  • MDL No. MFCD11848954
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₉N₃O
  • Molecular Weight 221.30
  • Synonym(s) 2-Methoxy-4-(4-methyl-piperazin-1-yl)-phenylamine
  • SMILES NC1=C(OC)C=C(C=C1)N2CCN(C)CC2

Description

2-Methoxy-4-(4-methylpiperazin-1-yl)aniline features a methoxy group and a sterically hindered methylpiperazinyl substituent on an aromatic scaffold, enhancing solubility and metabolic stability. This electron-rich aniline derivative serves as a key building block in medicinal chemistry, enabling efficient coupling reactions under mild conditions for targeted drug discovery applications.

Application

2-Methoxy-4-(4-methylpiperazin-1-yl)aniline serves as a versatile building block in medicinal chemistry, enabling the construction of diverse heterocyclic scaffolds through standard coupling and cyclization reactions. Its methoxy and piperazinyl functionalities offer enhanced solubility and tunable basicity, while the aniline core supports facile derivatization via electrophilic substitution or amide formation. Bench-stable and compatible with common purification methods, it functions effectively in multi-step synthesis for targeted API development.

Synthesis

  • Route1

    References

    • WO2011/79231 A1, ;
  • Route2

    References

    • WO2011/79231 A1, ;
  • Route3

    References

    • European Journal of Medicinal Chemistry, , vol. 77, p. 75 - 83

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   41.73
  • LogP   1.0292
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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