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CS-W001157 4
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4-(1-Methylpiperidin-4-yl)aniline

  • CAS No. 454482-12-3

  • Cat. No. CS-W019051
  • Purity≥98%
  • MDL No.MFCD06804550

*For research and further manufacturing use only, not for direct human use.

4-(1-Methylpiperidin-4-yl)aniline|CS-W019051

Structure of 454482-12-3

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General Information

  • CAS No. 454482-12-3
  • Cat. No. CS-W019051
  • Purity ≥98%
  • MDL No. MFCD06804550
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₈N₂
  • Molecular Weight 190.29
  • Synonym(s) 4-(1-METHYL-PIPERIDIN-4-YL)-ANILINE
  • SMILES CN1CCC(CC1)C2=CC=C(N)C=C2

Description

4-(1-Methylpiperidin-4-yl)aniline features a piperidine ring bearing a methyl group and an aniline moiety, delivering enhanced solubility and basicity. This structural combination enables efficient integration into pharmaceutical intermediates, particularly in kinase inhibitor scaffolds where its electron-rich aromatic system facilitates targeted receptor interactions.

Application

4-(1-Methylpiperidin-4-yl)aniline serves as a versatile building block in medicinal chemistry, enabling the construction of diverse heterocyclic scaffolds through standard coupling and cyclization protocols. Its amine functionality facilitates straightforward derivatization, while the piperidine ring offers favorable metabolic stability and tunable basicity. The compound exhibits good bench stability and is compatible with common purification methods, making it well-suited for iterative synthesis workflows in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.26
  • LogP   2.078
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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