4-(Dimethylamino)piperidine dihydrochloride

Name: 4-(Dimethylamino)piperidine dihydrochloride
Brand: ChemScene
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CAS No. 4876-59-9
Cat. No. CS-W002164
Purity≥96%
MDL No.MFCD00035296

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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4-(Dimethylamino)piperidine dihydrochloride|CS-W002164

Structure of 4876-59-9

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General Information

CAS No. 4876-59-9
Cat. No. CS-W002164
Purity ≥96%
MDL No. MFCD00035296
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₁₈Cl₂N₂
Molecular Weight 201.14
Synonym(s) 4-piperidinamine, N,N-dimethyl-, chloride
SMILES CN(C1CCNCC1)C.Cl.Cl

Description

4-(Dimethylamino)piperidine dihydrochloride is a bench-stable, moisture-tolerant amine derivative featuring a tertiary dimethylamino group that enhances nucleophilicity. This piperidine scaffold integrates readily into medicinal chemistry libraries, serving as a key building block for bioactive molecules requiring basic nitrogen functionality in drug discovery workflows.

Application

4-(Dimethylamino)piperidine dihydrochloride serves as a versatile nitrogen-containing building block in medicinal chemistry, enabling efficient construction of bioactive heterocycles. Its protonated form enhances solubility and stability in aqueous media, facilitating use in amine coupling reactions and reductive amination protocols. The dimethylamino group provides strong basicity and favorable electronic effects for transition metal catalysis, while the piperidine core offers conformational rigidity ideal for target-directed synthesis.

Synthesis

Route1
- 4876-56-6
- ~%
- In-stock
  
  4876-59-9
References
- AMGEN INC. Patent: WO2006/44823 A2, 2006 ; Location in patent: Page/Page column 147-148 ; WO 2006/044823 A2
Route2
- 412293-88-0
- ~%
- In-stock
  
  4876-59-9
References
- Diwan, Sachin S.; Dalvi, Sonali W.; Mulla, Hormuzd R. Synthetic Communications, 2009 , vol. 39, # 2 p. 273 - 277

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 15.27
LogP 1.1436
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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4-(Dimethylamino)piperidine dihydrochloride

CAS No. 4876-59-9

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