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CS-W001157 4
Total: USD 88.00

4,4-Dimethylpiperidine hydrochloride

  • CAS No. 38646-68-3

  • Cat. No. CS-W005691
  • Purity≥97%
  • MDL No.MFCD00035295

*For research and further manufacturing use only, not for direct human use.

4,4-Dimethylpiperidine hydrochloride|CS-W005691

Structure of 38646-68-3

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General Information

  • CAS No. 38646-68-3
  • Cat. No. CS-W005691
  • Purity ≥97%
  • MDL No. MFCD00035295
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₆ClN
  • Molecular Weight 149.66
  • Synonym(s) 4,4-dimethylpiperidinium chloride
  • SMILES CC1(C)CCNCC1.[H]Cl

Description

4,4-Dimethylpiperidine hydrochloride offers a sterically hindered, bench-stable nitrogen heterocycle ideal for medicinal chemistry applications. The quaternary nitrogen center enhances solubility and metabolic stability, while the dimethyl substitution reduces basicity compared to parent piperidines. This derivative integrates readily into bioactive molecules requiring persistent cationic character under physiological conditions.

Application

4,4-Dimethylpiperidine hydrochloride serves as a stable, bench-ready source of the 4,4-dimethylpiperidine moiety, enabling efficient incorporation into diverse synthetic scaffolds. Its well-defined basicity and improved solubility facilitate amine coupling reactions, reductive amination protocols, and salt formation in medicinal chemistry workflows. The tertiary amine functionality demonstrates robust functional group tolerance and compatibility with standard purification techniques, making it a reliable building block for API intermediates and heterocyclic synthesis.

Synthesis

  • Route1

    References

    • Mimura; Hayashida; Nomiyama; Ikegami; Iida; Tamura; Hiyama; Ohishi Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 11 p. 1971 - 1986
  • Route2
    • null|null
      4045-30-1
    • ~85%
    • In-stock
      4,4-Dimethylpiperidine hydrochloride|CS-W005691
      38646-68-3

    References

    • Wang, Jun; Cady, Sarah D.; Balannik, Victoria; Pinto, Lawrence H.; DeGrado, William F.; Hong, Mei Journal of the American Chemical Society, 2009 , vol. 131, p. 8066 - 8076
  • Route3
    • null|null
      92292-00-7
    • ~%
    • null|null
      1194-02-1
    • In-stock
      4,4-Dimethylpiperidine hydrochloride|CS-W005691
      38646-68-3

    References

    • Welfide Corporation Patent: US6288061 B1, 2001 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   1.8178
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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