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CS-W001157 4
Total: USD 88.00

2,6-Dimethylpyrimidin-4-ol

  • CAS No. 6622-92-0

  • Cat. No. CS-W013528
  • Purity≥98%
  • MDL No.MFCD00006105

*For research and further manufacturing use only, not for direct human use.

2,6-Dimethylpyrimidin-4-ol|CS-W013528

Structure of 6622-92-0

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General Information

  • CAS No. 6622-92-0
  • Cat. No. CS-W013528
  • Purity ≥98%
  • MDL No. MFCD00006105
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈N₂O
  • Molecular Weight None
  • Synonym(s) 6-hydroxy-2,4-dimethylyrimidine
  • SMILES CC1=NC(C)=NC(O)=C1

Description

2,6-Dimethylpyrimidin-4-ol features a sterically hindered pyrimidine core with a phenolic hydroxyl group, enabling robust hydrogen bonding and enhanced solubility in polar solvents. This bench-stable compound integrates readily into heterocyclic synthesis, serving as a key scaffold for medicinal chemistry and catalyst design.

Application

2,6-Dimethylpyrimidin-4-ol serves as a versatile building block in medicinal chemistry, enabling the construction of pyrimidine-based scaffolds prevalent in kinase inhibitors and antiviral agents. Its stability under standard reaction conditions, combined with predictable reactivity at the C4 hydroxyl group, facilitates straightforward derivatization via etherification, esterification, or metal-catalyzed coupling. The methyl groups at C2 and C6 enhance solubility and modulate electronic properties, offering favorable handling characteristics for high-throughput synthesis and process development.

Synthesis

  • Route1
    • null|null
      124-42-5
    • In-stock
      Ethyl acetoacetate|CS-0016216
      141-97-9
    • ~%
    • In-stock
      2,6-Dimethylpyrimidin-4-ol|CS-W013528
      6622-92-0

    References

    • Chemische Berichte, , vol. 22, p. 1610 Chemische Berichte, , vol. 23, p. 2925
  • Route2
    • null|null
      77752-49-9
    • ~32%
    • In-stock
      2,6-Dimethylpyrimidin-4-ol|CS-W013528
      6622-92-0
    • null|null
      65845-63-8

    References

    • Chemical and Pharmaceutical Bulletin, , vol. 29, # 1 p. 98 - 104
  • Route3
    • null|null
      87273-09-4
    • ~0%
    • In-stock
      2,6-Dimethylpyrimidin-4-ol|CS-W013528
      6622-92-0
    • null|null
      4159-03-9

    References

    • Singh, Harjit; Aggarwal, Sunil K.; Malhotra, Nageshwar Tetrahedron, 1984 , vol. 40, # 23 p. 4941 - 4946

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.01
  • LogP   0.79904
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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