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CS-W001157 4
Total: USD 88.00

(R)-1-[4-(Trifluoromethyl)phenyl]ethylamine

  • CAS No. 578027-35-7

  • Cat. No. CS-B0689
  • Purity≥95%
  • MDL No.MFCD06761837

*For research and further manufacturing use only, not for direct human use.

(R)-1-[4-(Trifluoromethyl)phenyl]ethylamine|CS-B0689

Structure of 578027-35-7

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General Information

  • CAS No. 578027-35-7
  • Cat. No. CS-B0689
  • Purity ≥95%
  • MDL No. MFCD06761837
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀F₃N
  • Molecular Weight 189.18
  • Synonym(s) R-PTF-PEM
  • SMILES FC(F)(F)C(C=C1)=CC=C1[C@@H](C)N

Description

(R)-1-[4-(Trifluoromethyl)phenyl]ethylamine is a chiral amine featuring a trifluoromethyl group at the para position of a phenyl ring. This configuration imparts enhanced metabolic stability and lipophilicity, making it a valuable building block in asymmetric synthesis. The molecule integrates readily into pharmaceutical intermediates and functionalized ligands.

Application

(R)-1-[4-(Trifluoromethyl)phenyl]ethylamine serves as a valuable chiral building block in medicinal chemistry, enabling the synthesis of asymmetric pharmaceutical intermediates. Its benzylic amine functionality exhibits good bench stability and compatibility with standard functional group manipulations. The trifluoromethyl group imparts enhanced metabolic stability and lipophilicity, making this scaffold particularly useful in drug discovery campaigns targeting CNS and oncology therapeutics.

Synthesis

  • Route1
    • null|null
      437762-12-4
    • null|null
      444643-05-4
    • ~%
    • In-stock
      (1S)-1-[4-(Trifluoromethyl)phenyl]ethylamine|CS-B0008
      84499-73-0
    • In-stock
      (R)-1-[4-(Trifluoromethyl)phenyl]ethylamine|CS-B0689
      578027-35-7

    References

    • US6797842 B2, ; Page column 25 ;
  • Route2
    • null|null
      721446-00-0
    • ~46%
    • In-stock
      (R)-1-[4-(Trifluoromethyl)phenyl]ethylamine|CS-B0689
      578027-35-7

    References

    • Lipshutz, Bruce H.; Shimizu, Hideo Angewandte Chemie - International Edition, 2004 , vol. 43, # 17 p. 2228 - 2230
  • Route3
    • null|null
      626244-14-2
    • ~%
    • In-stock
      (R)-1-[4-(Trifluoromethyl)phenyl]ethylamine|CS-B0689
      578027-35-7

    References

    • US2004/24253 A1, ; Page 7 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H319
Precautionary Statements : P264-P270-P280-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.7251
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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