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CS-W001157 4
Total: USD 88.00

(1S)-1-[4-(difluoromethyl)phenyl]ethylamine

  • CAS No. 1213446-58-2

  • Cat. No. CS-0162128
  • Molecule weight171.19
  • Purity≥98%
  • MDL No.MFCD09414827

*For research and further manufacturing use only, not for direct human use.

(1S)-1-[4-(difluoromethyl)phenyl]ethylamine|CS-0162128

Structure of 1213446-58-2

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General Information

  • CAS No. 1213446-58-2
  • Cat. No. CS-0162128
  • Purity ≥98%
  • MDL No. MFCD09414827
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁F₂N
  • Molecular Weight 171.19
  • Synonym(s) None
  • SMILES N[C@H](C1=CC=C(C(F)F)C=C1)C

Description

This chiral amine features a difluoromethyl-substituted phenyl group attached to a stereodefined ethylamine scaffold. The para-difluoromethyl moiety imparts enhanced metabolic stability and modulates electronic properties, making it valuable for synthesizing bioactive molecules in medicinal chemistry.

Application

(1S)-1-[4-(Difluoromethyl)phenyl]ethylamine serves as a valuable chiral building block in medicinal chemistry, enabling the synthesis of fluorinated arylalkylamines with defined stereochemistry. Its difluoromethyl group imparts enhanced metabolic stability and modulated lipophilicity, while the secondary amine facilitates straightforward derivatization. The compound exhibits good bench stability and is compatible with standard purification techniques, making it well-suited for use in multi-step synthesis and API development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.6439
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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