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CS-W001157 4
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(S)-1-(4-(Trifluoromethyl)phenyl)ethan-1-amine hydrochloride

  • CAS No. 84499-78-5

  • Cat. No. CS-0000152
  • Purity≥98%
  • MDL No.MFCD11035901

*For research and further manufacturing use only, not for direct human use.

(S)-1-(4-(Trifluoromethyl)phenyl)ethan-1-amine hydrochloride|CS-0000152

Structure of 84499-78-5

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General Information

  • CAS No. 84499-78-5
  • Cat. No. CS-0000152
  • Purity ≥98%
  • MDL No. MFCD11035901
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁ClF₃N
  • Molecular Weight 225.64
  • Synonym(s) (S)-1-(4-(Trifluoromethyl)phenyl)ethanamine hydrochloride
  • SMILES C[C@H](N)C1=CC=C(C(F)(F)F)C=C1.Cl

Description

(S)-1-(4-(Trifluoromethyl)phenyl)ethan-1-amine hydrochloride is a chiral amine featuring a trifluoromethyl-substituted phenyl group, delivering enhanced electron-withdrawing character and metabolic stability. This bench-stable hydrochloride salt facilitates straightforward handling in asymmetric synthesis, enabling efficient incorporation into pharmaceutical intermediates and functionalized building blocks.

Application

(S)-1-(4-(Trifluoromethyl)phenyl)ethan-1-amine hydrochloride serves as a valuable chiral building block in medicinal chemistry, enabling the synthesis of asymmetric pharmaceutical intermediates. Its trifluoromethyl aryl group imparts enhanced metabolic stability and lipophilicity, while the amine functionality facilitates straightforward derivatization via amidation, alkylation, or reductive amination. The hydrochloride salt ensures excellent bench stability and ease of handling, supporting scalable synthesis and purification in standard workflows.

Synthesis

  • Route1
    • null|null
      911372-69-5
    • ~81%
    • In-stock
      (S)-1-(4-(Trifluoromethyl)phenyl)ethan-1-amine hydrochloride|CS-0000152
      84499-78-5

    References

    • Colyer, John T.; Andersen, Neil G.; Tedrow, Jason S.; Soukup, Troy S.; Faul, Margaret M. Journal of Organic Chemistry, 2006 , vol. 71, # 18 p. 6859 - 6862
  • Route2
    • null|null
      911372-49-1
    • ~%
    • In-stock
      (S)-1-(4-(Trifluoromethyl)phenyl)ethan-1-amine hydrochloride|CS-0000152
      84499-78-5

    References

    • Journal of Organic Chemistry, , vol. 71, # 18 p. 6859 - 6862
  • Route3

    References

    • Journal of Organic Chemistry, , vol. 71, # 18 p. 6859 - 6862

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   3.1469
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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