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CS-W001157 4
Total: USD 88.00

(1S)-1-[4-(Trifluoromethyl)phenyl]ethylamine

  • CAS No. 84499-73-0

  • Cat. No. CS-B0008
  • Purity≥95%
  • MDL No.MFCD03093009

*For research and further manufacturing use only, not for direct human use.

(1S)-1-[4-(Trifluoromethyl)phenyl]ethylamine|CS-B0008

Structure of 84499-73-0

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General Information

  • CAS No. 84499-73-0
  • Cat. No. CS-B0008
  • Purity ≥95%
  • MDL No. MFCD03093009
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀F₃N
  • Molecular Weight 189.18
  • Synonym(s) benzenemethanamine, alpha-methyl-4-(trifluoromethyl)-, (alphaS)-
  • SMILES FC(F)(F)C1=CC=C([C@H](C)N)C=C1

Description

(1S)-1-[4-(Trifluoromethyl)phenyl]ethylamine features a chiral benzylic amine scaffold with a strongly electron-withdrawing trifluoromethyl group. This configuration imparts enhanced stereochemical stability and facilitates selective functionalization in asymmetric synthesis. The compound serves as a key enantioselective building block for pharmaceutical intermediates and ligands in catalytic systems.

Synthesis

  • Route1
    • null|null
      437762-12-4
    • null|null
      444643-05-4
    • ~%
    • In-stock
      (1S)-1-[4-(Trifluoromethyl)phenyl]ethylamine|CS-B0008
      84499-73-0
    • In-stock
      (R)-1-[4-(Trifluoromethyl)phenyl]ethylamine|CS-B0689
      578027-35-7

    References

    • US6797842 B2, ; Page column 25 ;
  • Route2
    • null|null
      437762-12-4
    • ~%
    • In-stock
      (1S)-1-[4-(Trifluoromethyl)phenyl]ethylamine|CS-B0008
      84499-73-0

    References

    • Organic Letters, , vol. 5, # 7 p. 1007 - 1010
  • Route3
    • null|null
      437762-12-4
    • ~%
    • 1-Ethyl-4-(trifluoromethyl)benzene|CS-0333394
      27190-69-8
    • In-stock
      (1S)-1-[4-(Trifluoromethyl)phenyl]ethylamine|CS-B0008
      84499-73-0

    References

    • Organic Letters, , vol. 5, # 7 p. 1007 - 1010

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H314
Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.7251
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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