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CS-W001157 4
Total: USD 88.00

4-Chloro-6-hydrazinylpyrimidine

  • CAS No. 5767-35-1

  • Cat. No. CS-0045843
  • Purity≥95%
  • MDL No.MFCD01646095

*For research and further manufacturing use only, not for direct human use.

4-Chloro-6-hydrazinylpyrimidine|CS-0045843

Structure of 5767-35-1

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General Information

  • CAS No. 5767-35-1
  • Cat. No. CS-0045843
  • Purity ≥95%
  • MDL No. MFCD01646095
  • Storage -20°C, stored under nitrogen, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅ClN₄
  • Molecular Weight 144.56
  • Synonym(s) 4-Chloro-6-hydrazinopyrimidine
  • SMILES C1=C(Cl)N=CN=C1NN

Description

4-Chloro-6-hydrazinylpyrimidine delivers a reactive hydrazino handle for conjugation chemistry, featuring a chloropyrimidine moiety that enables selective coupling under mild conditions. This bench-stable compound integrates readily into bioconjugates and functional materials, offering high reactivity with carbonyl groups and compatibility across diverse synthetic workflows.

Application

4-Chloro-6-hydrazinylpyrimidine serves as a versatile building block in heterocyclic synthesis, enabling efficient access to pyrimidine-based scaffolds through nucleophilic substitution and condensation reactions. The hydrazinyl group facilitates rapid cyclization with carbonyl-containing intermediates, while the chloro substituent provides a reliable handle for further functionalization via cross-coupling or displacement. Its bench-stable nature and compatibility with diverse reaction conditions make it valuable for medicinal chemistry campaigns and API intermediate development.

Synthesis

  • Route1

    References

    • IRM LLC; NOVARTIS AG Patent: WO2008/42639 A1, 2008 ; Location in patent: Page/Page column 81 ; WO 2008/042639 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501

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Computational Chemistry Data

  • TPSA   63.83
  • LogP   0.4156
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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