Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

6-Chloropyrimidin-4-amine

  • CAS No. 5305-59-9

  • Cat. No. CS-W001884
  • Purity≥97%
  • MDL No.MFCD00053576

*For research and further manufacturing use only, not for direct human use.

6-Chloropyrimidin-4-amine|CS-W001884

Structure of 5305-59-9

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 5305-59-9
  • Cat. No. CS-W001884
  • Purity ≥97%
  • MDL No. MFCD00053576
  • Storage -20°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₄ClN₃
  • Molecular Weight 129.55
  • Synonym(s) 6-chloro-4-aminopyrimidine
  • SMILES Nc1ncnc(c1)Cl

Description

6-Chloropyrimidin-4-amine serves as a critical heterocyclic building block in medicinal chemistry, featuring a chlorine atom at the 6-position and an amino group at the 4-position. This combination enables direct coupling in cross-coupling reactions and facilitates downstream derivatization in drug discovery pipelines. The molecule exhibits good stability under standard conditions and integrates readily into diverse molecular architectures.

Application

6-Chloropyrimidin-4-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds through nucleophilic substitution and transition-metal-catalyzed coupling reactions. Its moderate reactivity and bench stability facilitate straightforward functionalization at the C6 position, while the amino group supports further derivatization via acylation or alkylation. This compound functions effectively in the synthesis of kinase inhibitors and other bioactive heterocycles, offering predictable regiochemistry and compatibility with standard purification methods.

Synthesis

  • Route1

    References

    • Journal of Medicinal Chemistry, , vol. 54, # 20 p. 7066 - 7083
  • Route2

    References

    • US2005/227933 A1, ; Page/Page column 29 ; US 20050227933 A1
  • Route3
    • In-stock
      4,6-Dichloropyrimidine|CS-W018513
      1193-21-1
    • null|null
      71-36-3
    • ~%
    • In-stock
      6-Chloropyrimidin-4-amine|CS-W001884
      5305-59-9

    References

    • US2002/137755 A1, ; US 20020137755 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   51.8
  • LogP   0.7122
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 6-Chloropyrimidin-4-amine sigma6-Chloropyrimidin-4-amine manufacturer6-Chloropyrimidin-4-amine price6-Chloropyrimidin-4-amine structure6-Chloropyrimidin-4-amine SDSbuy 6-Chloropyrimidin-4-amine6-Chloropyrimidin-4-amine supplier6-Chloropyrimidin-4-amine uses6-Chloropyrimidin-4-amine molecular weightprice of 6-Chloropyrimidin-4-amine6-Chloropyrimidin-4-amine chemical name formula of 6-Chloropyrimidin-4-amine
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label