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CS-W001157 4
Total: USD 88.00

4,6-Dichloropyrimidine

  • CAS No. 1193-21-1

  • Cat. No. CS-W018513
  • Purity≥98%
  • MDL No.MFCD00006109
  • AREC Toxic Substance

*For research and further manufacturing use only, not for direct human use.

4,6-Dichloropyrimidine|CS-W018513

Structure of 1193-21-1

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General Information

  • CAS No. 1193-21-1
  • Cat. No. CS-W018513
  • Purity ≥98%
  • MDL No. MFCD00006109
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₂Cl₂N₂
  • Molecular Weight 148.98
  • Synonym(s) NSC 37530
  • SMILES ClC1=CC(Cl)=NC=N1

Description

Cyclic voltammograms of 4,6-dichloropyrimidine shows three cathodic waves, arising from sequential cleavage of carbon-chlorine bonds as well as the reduction of pyrimidine.4,6-Dichloropyrimidine was used in the synthesis of N-substituted azacalix[4]pyrimidines. It was used as starting reagent for the synthesis of disubstituted pyrimidines by tandem amination and Suzuki-Miyaura cross-coupling. It was also used in a biarylpyrimidine synthesis involving biaryl cross-coupling.

Synthesis

  • Route1

    References

    • Synlett, , # 14 art. no. W06110ST, p. 2179 - 2183
  • Route2
    • null|null
      75-44-5
    • null|null
      77287-34-4
    • null|null
      75-05-8
    • ~62%
    • In-stock
      4,6-Dichloropyrimidine|CS-W018513
      1193-21-1

    References

    • US2004/54181 A1, ; Page 8 ;
  • Route3
    • null|null
      75-44-5
    • In-stock
      4,6-Dihydroxypyrimidine|CS-W016618
      1193-24-4
    • ~79%
    • In-stock
      4,6-Dichloropyrimidine|CS-W018513
      1193-21-1

    References

    • US5750694 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3263
Class : 8
Packing Group : Ⅱ
Hazard Statements : H314-H318
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   1.7834
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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