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CS-W001157 4
Total: USD 88.00

4,6-Dichloro-2-iodopyrimidine

  • CAS No. 1266105-16-1

  • Cat. No. CS-0253929
  • Purity≥98%
  • MDL No.MFCD22207084

*For research and further manufacturing use only, not for direct human use.

4,6-Dichloro-2-iodopyrimidine|CS-0253929

Structure of 1266105-16-1

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General Information

  • CAS No. 1266105-16-1
  • Cat. No. CS-0253929
  • Purity ≥98%
  • MDL No. MFCD22207084
  • Storage -20°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄HCl₂IN₂
  • Molecular Weight None
  • Synonym(s) None
  • SMILES IC1=NC(Cl)=CC(Cl)=N1

Description

4,6-Dichloro-2-iodopyrimidine offers a highly reactive trifunctional pyrimidine scaffold featuring complementary halogen sites for sequential cross-coupling. The iodine moiety enables palladium-catalyzed coupling under mild conditions, while the chloro groups facilitate further functionalization via nucleophilic substitution or metal-mediated transformations. This reactivity profile supports rapid diversification in medicinal chemistry and materials synthesis.

Application

4,6-Dichloro-2-iodopyrimidine serves as a versatile building block for C–H functionalization and cross-coupling reactions in medicinal chemistry. The dichloro substitution pattern enables selective late-stage derivatization, while the iodine moiety facilitates palladium-catalyzed coupling with arylboranes, amines, and thiols. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for constructing substituted pyrimidine scaffolds commonly found in kinase inhibitors and antiviral agents.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   2.388
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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