Lot numbers can be found on the outside label of a product:
2-Fluoro-4-iodopyridine
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CAS No. 22282-70-8
- Cat. No. CS-B0944
- Purity≥98%
- MDL No.MFCD03092926
*For research and further manufacturing use only, not for direct human use.
Structure of 22282-70-8
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General Information
- CAS No. 22282-70-8
- Cat. No. CS-B0944
- Purity ≥98%
- MDL No. MFCD03092926
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₅H₃FIN
- Molecular Weight 222.99
- Synonym(s) 2-Fluor-4-iodpyridin
- SMILES IC1=CC(F)=NC=C1
Description
2-Fluoro-4-iodopyridine is a halogenated pyridine derivative featuring orthogonal reactivity between fluorine and iodine. This dual-functional motif enables selective cross-coupling transformations in late-stage diversification. The electron-deficient ring enhances compatibility with palladium catalysis, while the bench-stable nature simplifies handling in synthetic workflows.
Application
2-Fluoro-4-iodopyridine serves as a versatile building block in cross-coupling chemistry, enabling efficient Suzuki, Stille, and Negishi reactions due to its orthogonal reactivity profile. The fluorine and iodine substituents offer complementary functionalization potential, facilitating sequential transformations. Bench-stable and readily purified, it functions effectively in the synthesis of biologically active heterocycles and pharmaceutical intermediates.
Synthesis
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Route1
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In-stock
113975-22-7 - ~99%
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In-stock
22282-70-8
References
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Jonsson, Stefan; Odille, Fabrice G. J.; Norrby, Per-Ola; Waernmark, Kenneth Organic and Biomolecular Chemistry, 2006 , vol. 4, # 10 p. 1927 - 1948
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Route2
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372-48-5 - ~87%
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In-stock
22282-70-8
References
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Li, Qun; Li, Tongmei; Zhu, Gui-Dong; Gong, Jianchun; Claibone, Akiyo; Dalton, Chris; Luo, Yan; Johnson, Eric F.; Shi, Yan; Liu, Xuesong; Klinghofer, Vered; Bauch, Joy L.; Marsh, Kennan C.; Bouska, Jennifer J.; Arries, Shannon; De Jong, Ron; Oltersdorf, Tilman; Stoll, Vincent S.; Jakob, Clarissa G.; Rosenberg, Saul H.; Giranda, Vincent L. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 6 p. 1679 - 1685
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Route3
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372-48-5
- ~%
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In-stock
113975-22-7
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In-stock
22282-70-8
References
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US2005/20830 A1, ; Page 24 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 12.89
- LogP 1.8253
- H_Acceptors 1
- H_Donors 0
- Rotatable_Bonds 0
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Key Words
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