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CS-W001157 4
Total: USD 88.00

2,5-Difluoro-4-iodopyridine

  • CAS No. 1017793-20-2

  • Cat. No. CS-0005562
  • Purity≥98%
  • MDL No.MFCD11040606

*For research and further manufacturing use only, not for direct human use.

2,5-Difluoro-4-iodopyridine|CS-0005562

Structure of 1017793-20-2

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General Information

  • CAS No. 1017793-20-2
  • Cat. No. CS-0005562
  • Purity ≥98%
  • MDL No. MFCD11040606
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂F₂IN
  • Molecular Weight 240.98
  • Synonym(s) Pyridine,2,5-difluoro-4-iodo
  • SMILES IC1=CC(F)=NC=C1F

Description

2,5-Difluoro-4-iodopyridine delivers a strategically fluorinated and iodinated pyridine scaffold ideal for cross-coupling transformations. The electron-deficient ring pairs with the reactive iodide for efficient Pd-catalyzed bond formation, while the difluoro substitution enhances metabolic stability and modulates electronic properties in bioactive molecule synthesis.

Application

2,5-Difluoro-4-iodopyridine serves as a versatile building block in cross-coupling chemistry, enabling the construction of fluorinated heterocyclic scaffolds common in pharmaceutical development. The iodine substituent facilitates reliable Suzuki, Stille, and Negishi couplings, while the difluoro groups enhance metabolic stability and modulate electronic properties. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for iterative synthesis and late-stage functionalization in medicinal chemistry workflows.

Synthesis

  • Route1
    • null|null
      108-18-9
    • In-stock
      2,5-Difluoropyridine|CS-W003160
      84476-99-3
    • ~48%
    • In-stock
      2,5-Difluoro-4-iodopyridine|CS-0005562
      1017793-20-2

    References

    • WO2008/107125 A1, ; Page/Page column 43-44 ; WO 2008/107125 A1
  • Route2

    References

    • WO2011/73845 A1, ; Page/Page column 116-117 ; WO 2011/073845 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   1.9644
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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